IgA ASC 在哺乳期乳腺中的积累依赖于 VCAM-1 和 alpha4 整合素。
IgA ASC accumulation to the lactating mammary gland is dependent on VCAM-1 and alpha4 integrins.
机构信息
Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT 84602, USA.
出版信息
Mol Immunol. 2010 Apr;47(7-8):1608-12. doi: 10.1016/j.molimm.2010.01.015. Epub 2010 Feb 19.
Abstract
The homing and migration of IgA antibody secreting cells (ASC) to the lactating mammary gland is essential to the passive transfer of immunity from mother to nursing neonate. Antibody secreting cells, located within the lactating mammary gland, produce high levels of antigen-specific IgA antibodies. These antibodies, which are subsequently transferred to the nursing neonate via breast milk, provide passive immune protection against antigens previously encountered by the mother to the nursing infant. The efficient homing and accumulation of lymphocytes is highly dependent on cellular adhesion molecules expressed on the vascular endothelium and their integrin ligands. Vasculature within the lactating mammary gland is known to express several adhesion molecules, including VCAM-1 and MAdCAM-1. However, the role of these molecules in vivo has not been previously described. Here we show that alpha4 integrins and VCAM-1 play essential roles in mediating the accumulation of IgA ASCs to the lactating mammary gland. Conversely, neither MAdCAM-1 nor its major ligand alpha4beta7 are required for efficient IgA ASC accumulation to this tissue.
摘要
IgA 抗体分泌细胞 (ASC) 归巢和迁移到哺乳期乳腺对于将母体免疫被动转移到哺乳新生儿至关重要。位于哺乳期乳腺中的抗体分泌细胞产生高水平的抗原特异性 IgA 抗体。这些抗体随后通过母乳转移到哺乳新生儿，为新生儿提供针对母亲先前遇到的抗原的被动免疫保护。淋巴细胞的有效归巢和积累高度依赖于血管内皮细胞上表达的细胞间黏附分子及其整合素配体。已知哺乳期乳腺中的脉管系统表达几种黏附分子，包括 VCAM-1 和 MAdCAM-1。然而，这些分子在体内的作用以前尚未描述。在这里，我们表明 alpha4 整合素和 VCAM-1 在介导 IgA ASC 向哺乳期乳腺的积累中发挥重要作用。相反，MAdCAM-1 及其主要配体 alpha4beta7 对于 IgA ASC 向该组织的有效积累都不是必需的。
相似文献
1
IgA ASC accumulation to the lactating mammary gland is dependent on VCAM-1 and alpha4 integrins.IgA ASC 在哺乳期乳腺中的积累依赖于 VCAM-1 和 alpha4 整合素。
Mol Immunol. 2010 Apr;47(7-8):1608-12. doi: 10.1016/j.molimm.2010.01.015. Epub 2010 Feb 19.
2
CCL28 controls immunoglobulin (Ig)A plasma cell accumulation in the lactating mammary gland and IgA antibody transfer to the neonate.CCL28控制哺乳期乳腺中免疫球蛋白（Ig）A浆细胞的积聚以及IgA抗体向新生儿的转移。
J Exp Med. 2004 Sep 20;200(6):805-9. doi: 10.1084/jem.20041069.
3
New insights into the dual recruitment of IgA+ B cells in the developing mammary gland.发育中的乳腺中IgA + B细胞双重募集的新见解。
Mol Immunol. 2008 Jul;45(12):3354-62. doi: 10.1016/j.molimm.2008.04.017. Epub 2008 Jun 3.
4
Lymphocyte homing and Ig secretion in the murine mammary gland.小鼠乳腺中的淋巴细胞归巢与免疫球蛋白分泌
Scand J Immunol. 2001 Sep;54(3):292-300. doi: 10.1046/j.1365-3083.2001.00933.x.
5
Adhesion molecule expression in the bovine mammary gland.牛乳腺中黏附分子的表达
Vet Immunol Immunopathol. 2007 Feb 15;115(3-4):205-15. doi: 10.1016/j.vetimm.2006.10.020. Epub 2006 Nov 7.
6
An increase in milk IgA correlates with both pIgR expression and IgA plasma cell accumulation in the lactating mammary gland of PRM/Alf mice.在 PRM/Alf 小鼠的哺乳期乳腺中，牛奶 IgA 的增加与 pIgR 表达和 IgA 浆细胞的积累都相关。
J Reprod Immunol. 2012 Dec;96(1-2):25-33. doi: 10.1016/j.jri.2012.08.001. Epub 2012 Sep 25.
7
Differential recruitment of T- and IgA B-lymphocytes in the developing mammary gland in relation to homing receptors and vascular addressins.发育中的乳腺中T淋巴细胞和IgA B淋巴细胞与归巢受体及血管地址素相关的差异性募集
J Histochem Cytochem. 1999 Dec;47(12):1581-92. doi: 10.1177/002215549904701210.
8
Effects of coumestrol administration to maternal mice during pregnancy and lactation on immunoblogulin A-secreting cells in mammary glands.孕期和哺乳期给母鼠施用香豆雌酚对乳腺中免疫球蛋白 A 分泌细胞的影响。
Anim Sci J. 2013 Apr;84(4):322-7. doi: 10.1111/asj.12007. Epub 2012 Dec 3.
9
Supplemental β-carotene increases IgA-secreting cells in mammary gland and IgA transfer from milk to neonatal mice.补充β-胡萝卜素可增加乳腺中的 IgA 分泌细胞，并将 IgA 从乳汁转移到新生小鼠。
Br J Nutr. 2011 Jan;105(1):24-30. doi: 10.1017/S0007114510003089. Epub 2010 Aug 23.
10
CC chemokine ligands 25 and 28 play essential roles in intestinal extravasation of IgA antibody-secreting cells.C-C趋化因子配体25和28在分泌IgA抗体的细胞的肠道外渗过程中发挥着重要作用。
J Immunol. 2004 Sep 15;173(6):3668-75. doi: 10.4049/jimmunol.173.6.3668.
引用本文的文献
1
Mammary intraepithelial lymphocytes and intestinal inputs shape T cell dynamics in lactogenesis.乳腺上皮内淋巴细胞和肠道输入影响泌乳过程中的T细胞动态变化。
Nat Immunol. 2025 Aug;26(8):1411-1422. doi: 10.1038/s41590-025-02218-3. Epub 2025 Jul 29.
2
Unique Kinetics of the Human Milk Antibody Response to JYNNEOS Vaccine for Prevention of Monkey Pox: A Case Study.人乳对预防猴痘的JYNNEOS疫苗抗体反应的独特动力学：一项案例研究。
Breastfeed Med. 2024 Dec;19(12):974-979. doi: 10.1089/bfm.2024.0257. Epub 2024 Oct 2.
3
Vedolizumab Does Not Affect Antibody Secreting Cell Recruitment to the Lactating Mammary Gland of Mothers With Inflammatory Bowel Disease.维多珠单抗不影响抗体分泌细胞向患有炎症性肠病的母亲的泌乳乳腺募集。
Inflamm Bowel Dis. 2025 Jan 6;31(1):290-293. doi: 10.1093/ibd/izae023.
4
The Secretory IgA Response in Human Milk Against the SARS-CoV-2 Spike Is Highly Durable and Neutralizing for At Least 1 Year of Lactation Postinfection.人乳中针对 SARS-CoV-2 刺突的分泌型 IgA 反应具有高度持久性和中和作用，至少在感染后 1 年的哺乳期内有效。
Breastfeed Med. 2023 Aug;18(8):602-611. doi: 10.1089/bfm.2023.0117.
5
Assessment of human milk samples obtained pre and post-influenza vaccination reveals a poor boosting of seasonally-relevant, hemagglutinin-specific antibodies.评估流感疫苗接种前后获得的人乳样本显示，季节性相关的血凝素特异性抗体的增强效果不佳。
Front Immunol. 2023 May 31;14:1154782. doi: 10.3389/fimmu.2023.1154782. eCollection 2023.
6
The secretory IgA (sIgA) response in human milk against the SARS-CoV-2 Spike is highly durable and neutralizing for at least 1 year of lactation post-infection.人乳中针对新冠病毒刺突蛋白的分泌型免疫球蛋白A（sIgA）反应具有高度持久性，且在感染后至少1年的哺乳期内都具有中和作用。
medRxiv. 2023 May 26:2023.05.19.23290192. doi: 10.1101/2023.05.19.23290192.
7
Dormant reporter-marked basal stem/progenitor cells contribute to mammary lobuloalveoli formation.处于休眠状态的报告基因标记的基底干细胞/祖细胞有助于乳腺小叶腺泡的形成。
iScience. 2022 Feb 26;25(3):103982. doi: 10.1016/j.isci.2022.103982. eCollection 2022 Mar 18.
8
Infectious episodes during pregnancy, at particular mucosal sites, increase specific IgA1 or IgA2 subtype levels in human colostrum.孕期特定黏膜部位发生的感染会增加人初乳中特异性IgA1或IgA2亚型的水平。
Matern Health Neonatol Perinatol. 2019 Jun 11;5:9. doi: 10.1186/s40748-019-0104-x. eCollection 2019.
9
Mucosal Immunity in the Female Murine Mammary Gland.雌性鼠类乳腺中的黏膜免疫。
J Immunol. 2018 Jul 15;201(2):734-746. doi: 10.4049/jimmunol.1800023. Epub 2018 Jun 8.
10
Protection against Pertussis in Humans Correlates to Elevated Serum Antibodies and Memory B Cells.人类对百日咳的免疫力与血清抗体和记忆B细胞水平升高相关。
Front Immunol. 2017 Sep 15;8:1158. doi: 10.3389/fimmu.2017.01158. eCollection 2017.
本文引用的文献
1
Mucosal addressin cell-adhesion molecule-1 controls plasma-cell migration and function in the small intestine of mice.黏膜地址素细胞黏附分子-1调控小鼠小肠中浆细胞的迁移和功能。
Gastroenterology. 2009 Sep;137(3):924-33. doi: 10.1053/j.gastro.2009.05.039. Epub 2009 May 18.
2
An indispensable role for the chemokine receptor CCR10 in IgA antibody-secreting cell accumulation.趋化因子受体CCR10在分泌IgA抗体的细胞积聚中起不可或缺的作用。
J Immunol. 2008 Nov 1;181(9):6309-15. doi: 10.4049/jimmunol.181.9.6309.
3
New insights into the dual recruitment of IgA+ B cells in the developing mammary gland.发育中的乳腺中IgA + B细胞双重募集的新见解。
Mol Immunol. 2008 Jul;45(12):3354-62. doi: 10.1016/j.molimm.2008.04.017. Epub 2008 Jun 3.
4
CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow.CCL25和CCL28在剪切流作用下促进淋巴细胞通过α4β7整合素依赖的方式黏附于黏膜地址素细胞黏附分子-1（MAdCAM-1）。
Am J Physiol Gastrointest Liver Physiol. 2008 May;294(5):G1257-67. doi: 10.1152/ajpgi.00266.2007. Epub 2008 Feb 28.
5
Redundant role of chemokines CCL25/TECK and CCL28/MEC in IgA+ plasmablast recruitment to the intestinal lamina propria after rotavirus infection.趋化因子CCL25/TECK和CCL28/MEC在轮状病毒感染后IgA+浆母细胞募集至小肠固有层中的多余作用
J Immunol. 2006 May 15;176(10):5749-59. doi: 10.4049/jimmunol.176.10.5749.
6
CCL28 controls immunoglobulin (Ig)A plasma cell accumulation in the lactating mammary gland and IgA antibody transfer to the neonate.CCL28控制哺乳期乳腺中免疫球蛋白（Ig）A浆细胞的积聚以及IgA抗体向新生儿的转移。
J Exp Med. 2004 Sep 20;200(6):805-9. doi: 10.1084/jem.20041069.
7
CC chemokine ligands 25 and 28 play essential roles in intestinal extravasation of IgA antibody-secreting cells.C-C趋化因子配体25和28在分泌IgA抗体的细胞的肠道外渗过程中发挥着重要作用。
J Immunol. 2004 Sep 15;173(6):3668-75. doi: 10.4049/jimmunol.173.6.3668.
8
Chemokine receptor CCR9 contributes to the localization of plasma cells to the small intestine.趋化因子受体CCR9有助于浆细胞定位于小肠。
J Exp Med. 2004 Feb 2;199(3):411-6. doi: 10.1084/jem.20030996. Epub 2004 Jan 26.
9
Plasma-cell homing.浆细胞归巢
Nat Rev Immunol. 2003 Oct;3(10):822-9. doi: 10.1038/nri1203.
10
The transfer of immunity from mother to child.免疫力从母亲到孩子的传递。
Ann N Y Acad Sci. 2003 Apr;987:199-206. doi: 10.1111/j.1749-6632.2003.tb06049.x.
Zotero 插件