Rubin Bruce K
Department of Pediatrics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.
Otolaryngol Clin North Am. 2010 Feb;43(1):27-34, vii-viii. doi: 10.1016/j.otc.2009.11.002.
A variety of mucoactive medications are used to treat chronic lung disease. When evaluating the role of the cough, it must be considered as an important protective mechanism. Therefore, it may be more important to improve the effectiveness of cough than to suppress or eliminate a chronic cough in patients with chronic lung disease. This article discusses the composition of mucus and phlegm, the process of mucin secretion and mucus clearance, and reviews current therapy and mucolytics in use or being studied for mucus clearance disorders.
多种黏液活性药物用于治疗慢性肺部疾病。在评估咳嗽的作用时，必须将其视为一种重要的保护机制。因此，对于慢性肺部疾病患者，提高咳嗽的有效性可能比抑制或消除慢性咳嗽更为重要。本文讨论了黏液和痰液的组成、黏蛋白分泌和黏液清除过程，并综述了目前用于或正在研究用于黏液清除障碍的治疗方法和黏液溶解剂。
