Environmental and Molecular Toxicology Department, Oregon State University, ALS 1007, Corvallis, OR 97331, USA.
Chemosphere. 2010 Mar;79(1):1-7. doi: 10.1016/j.chemosphere.2010.02.001. Epub 2010 Feb 20.
The Biological Response Indicator Devices Gauging Environmental Stressors (BRIDGES) bio-analytical tool was developed in response to the need for a quantitative technology for assessing the toxicity of environmentally relevant contaminant mixtures. This tool combines passive samplers with the embryonic zebrafish model. When applied in an urban river it effectively linked site specific, bioavailable contaminant mixtures to multiple biological responses. Embryonic zebrafish exposed to extracts from lipid-free passive samplers that were deployed at five locations, within and outside of the Portland Harbor Superfund Megasite, displayed different responses. Six of the eighteen biological responses observed in 941 exposed zebrafish were significantly different between sites. This demonstrates the sensitivity of the bio-analytical tool for detecting spatially distinct toxicity in aquatic systems; bridging environmental exposure to biological response.
生物反应指示设备评估环境胁迫物（BRIDGES）生物分析工具是为了满足评估具有环境相关性的污染物混合物毒性的定量技术需求而开发的。该工具将被动采样器与胚胎斑马鱼模型相结合。当应用于城市河流时，它有效地将特定地点的、生物可利用的污染物混合物与多种生物反应联系起来。暴露于在波特兰港超级基金特大污染区内外五个地点部署的无脂被动采样器提取物中的胚胎斑马鱼表现出不同的反应。在 941 条暴露的斑马鱼中观察到的 18 种生物反应中有 6 种在地点之间存在显著差异。这表明该生物分析工具具有检测水生系统中空间上不同毒性的敏感性，从而将环境暴露与生物反应联系起来。
