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1
Human decidual NK cells from gravid uteri and NK cells from cycling endometrium are distinct NK cell subsets.人妊娠子宫中的蜕膜自然杀伤（NK）细胞和周期性子宫内膜中的 NK 细胞是不同的 NK 细胞亚群。
Placenta. 2010 Apr;31(4):334-8. doi: 10.1016/j.placenta.2010.01.003. Epub 2010 Feb 20.
2
The effect of pregnancy on the uterine NK cell KIR repertoire.妊娠对子宫 NK 细胞 KIR 谱的影响。
Eur J Immunol. 2011 Oct;41(10):3017-27. doi: 10.1002/eji.201141445. Epub 2011 Aug 30.
3
The unique properties of uterine NK cells.子宫 NK 细胞的独特特性。
Am J Reprod Immunol. 2010 Jun;63(6):434-44. doi: 10.1111/j.1600-0897.2009.00794.x. Epub 2010 Jan 4.
4
Understanding the heterogeneity of natural killer cells at the maternal-fetal interface: implications for pregnancy health and disease.了解母胎界面自然杀伤细胞的异质性：对妊娠健康与疾病的影响。
Mol Hum Reprod. 2024 Nov 14;30(11). doi: 10.1093/molehr/gaae040.
5
[Expression and significance of chemokine CXC receptor 3, 4 and their ligands at the early pregnancy decidua and villi].趋化因子CXC受体3、4及其配体在早孕蜕膜和绒毛中的表达及意义
Zhonghua Fu Chan Ke Za Zhi. 2008 Dec;43(12):904-8.
6
Human Innate Lymphoid Cells: Their Functional and Cellular Interactions in Decidua.人类先天淋巴细胞：在蜕膜中的功能和细胞相互作用。
Front Immunol. 2018 Aug 14;9:1897. doi: 10.3389/fimmu.2018.01897. eCollection 2018.
7
Phenotypic and functional characterization of rhesus monkey decidual lymphocytes: rhesus decidual large granular lymphocytes express CD56 and have cytolytic activity.恒河猴蜕膜淋巴细胞的表型和功能特征：恒河猴蜕膜大颗粒淋巴细胞表达CD56并具有细胞溶解活性。
J Reprod Immunol. 2001 Apr;50(1):57-79. doi: 10.1016/s0165-0378(00)00090-5.
8
Mechanisms underlying recruitment and accumulation of decidual NK cells in uterus during pregnancy.孕期子宫中蜕膜自然杀伤细胞募集和聚集的潜在机制。
Am J Reprod Immunol. 2008 May;59(5):417-24. doi: 10.1111/j.1600-0897.2008.00598.x.
9
Concordance between peripheral and decidual NK cell subsets and killer immunoglobulin-like receptors in women with recurrent spontaneous miscarriages.外周血和蜕膜 NK 细胞亚群与复发性自然流产妇女杀伤免疫球蛋白样受体的一致性。
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Normal murine and porcine embryos recruit NK cells to the uterus.正常的小鼠和猪胚胎会将自然杀伤细胞募集到子宫。
Cell Immunol. 1988 Sep;115(2):471-80. doi: 10.1016/0008-8749(88)90199-2.

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1
Uterine macrophages and NK cells exhibit population and gene-level changes after implantation but maintain pro-invasive properties.子宫巨噬细胞和自然杀伤细胞在着床后表现出群体和基因水平的变化，但仍保持着侵袭性。
Front Immunol. 2024 Mar 19;15:1364036. doi: 10.3389/fimmu.2024.1364036. eCollection 2024.
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BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth.BAFF 和 APRIL 拮抗调节炎症诱导的早产易感性。
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The Regulators of Human Endometrial Stromal Cell Decidualization.人类子宫内膜基质细胞蜕膜化的调节因子。
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Killer Timing: The Temporal Uterine Natural Killer Cell Differentiation Pathway and Implications for Female Reproductive Health.杀手的时机：子宫自然杀伤细胞的时间分化途径及其对女性生殖健康的影响。
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Dynamic Changes in Uterine NK Cell Subset Frequency and Function Over the Menstrual Cycle and Pregnancy.子宫 NK 细胞亚群频率和功能在月经周期和妊娠期间的动态变化。
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7
Uterine natural killer cell biology and role in early pregnancy establishment and outcomes.子宫自然杀伤细胞生物学及其在早期妊娠建立和结局中的作用。
F S Rev. 2021 Oct;2(4):265-286. doi: 10.1016/j.xfnr.2021.06.002. Epub 2021 Jun 23.
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A microphysiological model of human trophoblast invasion during implantation.人类着床过程中滋养细胞侵袭的微生理模型。
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9
Role of Natural Killer Cells during Pregnancy and Related Complications.自然杀伤细胞在妊娠及相关并发症中的作用。
Biomolecules. 2022 Jan 4;12(1):68. doi: 10.3390/biom12010068.
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Medawar's PostEra: Galectins Emerged as Key Players During Fetal-Maternal Glycoimmune Adaptation.梅达沃后时代：半乳糖凝集素在胎母糖免疫适应中崭露头角，成为关键角色。
Front Immunol. 2021 Dec 15;12:784473. doi: 10.3389/fimmu.2021.784473. eCollection 2021.

本文引用的文献

1
HLA-G homodimer-induced cytokine secretion through HLA-G receptors on human decidual macrophages and natural killer cells.HLA-G同型二聚体通过人蜕膜巨噬细胞和自然杀伤细胞上的HLA-G受体诱导细胞因子分泌。
Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5767-72. doi: 10.1073/pnas.0901173106. Epub 2009 Mar 20.
2
Endometrial NK cells are special immature cells that await pregnancy.子宫内膜自然杀伤细胞是等待受孕的特殊未成熟细胞。
J Immunol. 2008 Aug 1;181(3):1869-76. doi: 10.4049/jimmunol.181.3.1869.
3
Unique characteristics of NK cells throughout the human female reproductive tract.自然杀伤细胞在整个人类女性生殖道中的独特特征。
Clin Immunol. 2007 Jul;124(1):69-76. doi: 10.1016/j.clim.2007.04.008. Epub 2007 May 23.
4
Angiogenic factors and natural killer (NK) cells in the pathogenesis of preeclampsia.血管生成因子与自然杀伤（NK）细胞在子痫前期发病机制中的作用
J Reprod Immunol. 2007 Dec;76(1-2):23-9. doi: 10.1016/j.jri.2007.03.018. Epub 2007 May 9.
5
NK cell function in the human female reproductive tract.自然杀伤细胞在人类女性生殖道中的功能。
Am J Reprod Immunol. 2007 Feb;57(2):108-15. doi: 10.1111/j.1600-0897.2006.00448.x.
6
Decidual NK cells regulate key developmental processes at the human fetal-maternal interface.蜕膜自然杀伤细胞调节人类胎儿-母体界面的关键发育过程。
Nat Med. 2006 Sep;12(9):1065-74. doi: 10.1038/nm1452. Epub 2006 Aug 6.
7
Activation of NK cells by an endocytosed receptor for soluble HLA-G.可溶性 HLA - G 的内吞受体对自然杀伤细胞的激活作用。
PLoS Biol. 2006 Jan;4(1):e9. doi: 10.1371/journal.pbio.0040009.
8
Human decidual NK cells form immature activating synapses and are not cytotoxic.人蜕膜自然杀伤细胞形成未成熟的激活突触，且无细胞毒性。
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15563-8. doi: 10.1073/pnas.0507835102. Epub 2005 Oct 17.
9
Unique phenotype of human uterine NK cells and their regulation by endogenous TGF-beta.人子宫自然杀伤细胞的独特表型及其受内源性转化生长因子-β的调控
J Leukoc Biol. 2004 Sep;76(3):667-75. doi: 10.1189/jlb.0204090. Epub 2004 Jun 3.
10
Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential.人蜕膜自然杀伤细胞是具有免疫调节潜能的独特自然杀伤细胞亚群。
J Exp Med. 2003 Oct 20;198(8):1201-12. doi: 10.1084/jem.20030305.

人妊娠子宫中的蜕膜自然杀伤（NK）细胞和周期性子宫内膜中的 NK 细胞是不同的 NK 细胞亚群。

Human decidual NK cells from gravid uteri and NK cells from cycling endometrium are distinct NK cell subsets.

机构信息

Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.

出版信息

Placenta. 2010 Apr;31(4):334-8. doi: 10.1016/j.placenta.2010.01.003. Epub 2010 Feb 20.

DOI:10.1016/j.placenta.2010.01.003
PMID:20172608
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2943934/
Abstract

Human NK cells from the decidua basalis of gravid uteri and from the cycling endometrium of women undergoing hysterectomy were isolated and compared by gene expression profiling using Affymetrix microarrays with probes representing approximately 47,400 transcripts. Substantial differences indicate that these two types of NK cells represent distinct subsets.

摘要

通过使用 Affymetrix 微阵列和大约 47400 个转录本的探针进行基因表达谱分析，从妊娠子宫的蜕膜基底和接受子宫切除术的女性的周期性子宫内膜中分离和比较了人自然杀伤 (NK) 细胞。大量差异表明这两种类型的 NK 细胞代表不同的亚群。