Bi Xiao-Jiao, Lv Xiao-Min, Ai Xian-Ying, Sun Meng-Meng, Cui Kai-Yan, Yang Li-Min, Wang Li-Na, Yin Ai-Hua, Liu Lan-Fen
Department of Psychiatry, Shandong Mental Health Center, Jinan, Shandong Province, P.R. China.
Medicine (Baltimore). 2018 Mar;97(13):e0160. doi: 10.1097/MD.0000000000010160.
The gene - environment (G × E) interaction effect is involved in severe mental disorders. However, whether the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism participates in the childhood-abuse influenced schizophrenic symptoms remains unclear. We examined the interaction between BDNF Val66Met, and childhood trauma (ChT) on psychotic symptoms in a Chinese Han population.To estimate the G × E interaction, psychiatric interviews, self-report questionnaires for ChT, and genotyping for BDNF Val66Met were carried out on 201 schizophrenic patients. G × E interactions were analyzed by generalized multifactor dimensionality reduction (GMDR).Among all patients, 11.9%, 19.4%, 23.4%, 26.4%, and 73.6% reported emotional abuses, physical abuses (PA), sexual abuses (SA), emotional neglects (EN), and physical neglects (PN), respectively. Significant negative correlations were observed between anxiety/depression factors, and ChT total scores. Patients with 3 different BDNF genotypes showed significant differences in anxiety/depression scores. Significant 2-way interactions were found for Val66Met × PN, 3-way interactions were found for Val66Met × PN × PA, and four-way interactions were found for Val66Met × PN × PA × EN with regard to the excitement scores.Our findings suggested an involvement of BDNF Val66Met polymorphism after ChT in terms of risk for schizophrenia symptoms.
基因-环境（G×E）相互作用效应与严重精神障碍有关。然而，脑源性神经营养因子（BDNF）Val66Met多态性是否参与童年期虐待影响的精神分裂症症状仍不清楚。我们在中国汉族人群中研究了BDNF Val66Met与童年创伤（ChT）对精神病症状的相互作用。为了评估G×E相互作用，我们对201例精神分裂症患者进行了精神科访谈、ChT自我报告问卷以及BDNF Val66Met基因分型。通过广义多因素降维法（GMDR）分析G×E相互作用。在所有患者中，分别有11.9%、19.4%、23.4%、26.4%和73.6%的患者报告有情感虐待、身体虐待（PA）、性虐待（SA）、情感忽视（EN）和身体忽视（PN）。焦虑/抑郁因子与ChT总分之间存在显著负相关。具有3种不同BDNF基因型的患者在焦虑/抑郁评分上存在显著差异。在兴奋评分方面，发现Val66Met×PN存在显著的双向相互作用，Val66Met×PN×PA存在三向相互作用，Val66Met×PN×PA×EN存在四向相互作用。我们的研究结果表明，ChT后BDNF Val66Met多态性与精神分裂症症状风险有关。
