Molecular OncoSurgery, University of Heidelberg, German Cancer Research Center, Im Neuenheimer Feld 365, 69120 Heidelberg, Germany.
Cancer Treat Rev. 2010 Aug;36(5):377-83. doi: 10.1016/j.ctrv.2010.01.002. Epub 2010 Feb 20.
Over the past several decades, research on the action of bioactive constituents of plants has focused predominantly on their cancer-preventive properties. Today it can be explained why the consumption of fruits and vegetables may lead to a reduced frequency of certain cancer entities and why certain foods have therapeutic effects. Secondary plant products and especially glucosinolates from vegetables of the cruciferae family are supposed to have anti-carcinogenic potential. The present article gives an overview about secondary plant products in general and focuses to mechanisms of preventive and therapeutic effects of cruciferae, particular the brassica family and their famous member broccoli. Also, this article summarizes our knowledge of safety, tolerance and metabolism of glucosinolates and their therapeutic active degradation products isothiocyanates in animals and clinical studies.
在过去的几十年中，植物生物活性成分的作用研究主要集中在其预防癌症的特性上。如今，我们可以解释为什么食用水果和蔬菜可能会降低某些癌症实体的发病率，以及为什么某些食物具有治疗作用。次生植物产物，特别是十字花科蔬菜中的硫代葡萄糖苷，据推测具有抗癌潜力。本文概述了次生植物产物的一般特性，并重点介绍了十字花科植物（特别是芸薹属）及其著名成员西兰花的预防和治疗作用的机制。此外，本文还总结了我们对硫代葡萄糖苷及其治疗活性降解产物异硫氰酸盐在动物和临床研究中的安全性、耐受性和代谢的了解。
