Ukoli Flora A, Fowke Jay H, Akumabor Phillip, Oguike Temple, Taher Khandaker A, Murff Harvey J, Amaefuna Emeka R, Kittles Rick, Ahaghotu Chiledum, Osime Usifo, Beech Derrick J
Dept. of Surgery, Meharry Medical College, Nashville, TN 37208, USA.
J Health Care Poor Underserved. 2010 Feb;21(1 Suppl):127-47. doi: 10.1353/hpu.0.0242.
Higher risk for prostate cancer (PCa) among African Americans is partly associated with exposure to dietary fatty-acids, the carcinogenic effects of which remain controversial. Odds ratio of PCa risk was determined by unconditional logistic regression comparing highest with lowest quartiles of plasma fatty-acids in a case-control design. Mean age for 173 African Americans and 340 Nigerians was 56.9 +/- 9.8 and 60.1 +/- 14.0, p<.006, median (25th, 75th percentile) plasma fatty-acid was 2598 (2306, 3035) microg/ml and 2420 (2064, 2795) microg/ml, p<.001, with 48 (27.7%) and 66 (19.4%) PCa cases, respectively. African Americans recorded higher total, omega-6, and trans, but lower saturated and omega-3 fatty-acids, with non-significant PCa risk association for total, omega-6 and trans fatty acids. Positive PCa risk trend was observed in both populations with nervonic, erucic, and arachidonic acids, with docosahexaenoic acid (DHA) among African Americans, and with behenic and stearic acids in Nigerians. Non-significant negative PCa risk trend was observed with ecosapentaenoic acid (EPA) in Nigerians only. These preliminary findings need to be further explored in a larger study that will include risk analysis of fatty-acid ratios to clarify their combined impact on PCa risk.
非裔美国人患前列腺癌（PCa）的风险较高，部分原因与饮食中脂肪酸的摄入有关，但其致癌作用仍存在争议。在病例对照研究中，通过无条件逻辑回归比较血浆脂肪酸最高四分位数与最低四分位数，确定PCa风险的优势比。173名非裔美国人和340名尼日利亚人的平均年龄分别为56.9±9.8岁和60.1±14.0岁，p<0.006，血浆脂肪酸中位数（第25、75百分位数）分别为2598（2306，3035）μg/ml和2420（2064，2795）μg/ml，p<0.001，PCa病例分别为48例（27.7%）和66例（19.4%）。非裔美国人的总脂肪酸、ω-6脂肪酸和反式脂肪酸含量较高，但饱和脂肪酸和ω-3脂肪酸含量较低，总脂肪酸、ω-6脂肪酸和反式脂肪酸与PCa风险的关联不显著。在这两个人群中，神经酸、芥酸和花生四烯酸与PCa风险呈正相关趋势，非裔美国人中二十二碳六烯酸（DHA）与PCa风险呈正相关趋势，尼日利亚人中山嵛酸和硬脂酸与PCa风险呈正相关趋势。仅在尼日利亚人中，二十碳五烯酸（EPA）与PCa风险呈不显著的负相关趋势。这些初步研究结果需要在更大规模的研究中进一步探索，该研究将包括脂肪酸比例的风险分析，以阐明它们对PCa风险的综合影响。
