Chua Michael E, Sio Maria Christina D, Sorongon Mishell C, Morales Marcelino L
Institute of Urology and Research and Biotechnology Division, St. Luke's Medical Center, Philippines;
Can Urol Assoc J. 2013 May-Jun;7(5-6):E333-43. doi: 10.5489/cuaj.1056.
Our objective was to systematically analyze the evidence for an association between serum level long chain omega-3 polyunsaturated fatty acid (n-3 PUFA) and prostate cancer risk from human epidemiological studies. STUDY PROCEDURES: We searched biomedical literature databases up to November 2011 and included epidemiological studies with description of long chain n-3 PUFA and incidence of prostate cancer in humans. Critical appraisal was done by two independent reviewers. Data were pooled using the general variance-based method with random-effects model; effect estimates were expressed as risk ratio with 95% confidence interval (CI). Heterogeneity was assessed by Chi(2) and quantified by I(2), publication bias was also determined.
In total, 12 studies were included. Significant negative association was noted between high serum level of n-3 PUFA doc-osapentaenoic acid (DPA) and total prostate cancer risk (RR:0.756; 95% CI 0.599, 0.955; p = 0.019). Likewise, a positive association between high blood level of fish oil contents, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and high-grade prostate tumour incidence (RR:1.381; 95% CI 1.050, 1.817; p = 0.021) was noted; however, this finding was evident only after adjustment was done on interstudy variability through the removal of a lower quality study from the pool.
High serum levels of long chain n-3 PUFA DPA is associated with reduced total prostate cancer risk. While high blood level of EPA and DHA is possibly associated with increased high-grade prostate tumour risk.
我们的目的是系统分析人类流行病学研究中血清长链ω-3多不饱和脂肪酸（n-3 PUFA）与前列腺癌风险之间关联的证据。
我们检索了截至2011年11月的生物医学文献数据库，并纳入了描述长链n-3 PUFA与人类前列腺癌发病率的流行病学研究。由两名独立评审员进行批判性评估。使用基于一般方差的随机效应模型合并数据；效应估计值以风险比及95%置信区间（CI）表示。通过卡方检验评估异质性，并用I²进行量化，还确定了发表偏倚。
总共纳入了12项研究。血清中高浓度的n-3多不饱和脂肪酸二十二碳五烯酸（DPA）与前列腺癌总风险之间存在显著负相关（RR：0.756；95% CI 0.599，0.955；p = 0.019）。同样，血液中高浓度的鱼油成分、二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）与高级别前列腺肿瘤发病率之间存在正相关（RR：1.381；95% CI 1.050，1.817；p = 0.021）；然而，只有在通过从数据集中剔除一项质量较低的研究来调整研究间变异性之后，这一发现才明显。
血清中高浓度的长链n-3 PUFA DPA与前列腺癌总风险降低相关。而血液中高浓度的EPA和DHA可能与高级别前列腺肿瘤风险增加相关。
