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In vitro characterization of cardiac radiofrequency ablation lesions using optical coherence tomography.

作者信息

Fleming Christine P, Quan Kara J, Wang Hui, Amit Guy, Rollins Andrew M

机构信息

Case Western Reserve University. Biomedical Engineering Department. Cleveland, OH 44106, USA.

出版信息

Opt Express. 2010 Feb 1;18(3):3079-92. doi: 10.1364/OE.18.003079.

DOI:10.1364/OE.18.003079
PMID:20174138
Abstract

Currently, cardiac radiofrequency ablation (RFA) is guided by indirect signals. We demonstrate optical coherence tomography (OCT) characterization of RFA lesions within swine ventricular wedges. Untreated tissue exhibited a consistent birefringence artifact within OCT images due to the organized myocardium, which was not present in treated tissue. Birefringence artifacts were detected by filtering with a Laplacian of Gaussian (LoG) to quantify gradient strength. The gradient strength distinguished RFA lesions from untreated sites (p=5.93 x 10(-15)) with a sensitivity and specificity of 94.5% and 86.7% respectively. This study demonstrates the potential of OCT for monitoring cardiac RFA, confirming lesion formation and providing feedback to avoid complications.

摘要

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