A型胆囊收缩素受体介导胆囊收缩素-8对9至12日龄幼鼠食物摄入和活动的抑制作用。
Type-A CCK receptors mediate the inhibition of food intake and activity by CCK-8 in 9- to 12-day-old rat pups.
作者信息
Smith G P, Tyrka A, Gibbs J
机构信息
Department of Psychiatry, Cornell University Medical College, White Plains, NY.
出版信息
Pharmacol Biochem Behav. 1991 Jan;38(1):207-10. doi: 10.1016/0091-3057(91)90612-6.
To determine the type of cholecystokinin (CCK) receptor that mediates the inhibitory effects of peripherally administered CCK-8 on food intake and activity in 9- to 12-day-old rat pups, we gave injections of a type-A CCK receptor antagonist, MK-329, or of the type-B CCK receptor antagonist, L-365,260, prior to CCK-8 (IP). MK-329 reversed the inhibitory effects of CCK-8, but L-365,260 did not. This demonstrates that the inhibitory effects of CCK-8 (IP) are mediated by type-A, but not type-B, CCK receptors in pups of this age.
为了确定介导外周给予的胆囊收缩素八肽（CCK-8）对9至12日龄幼鼠食物摄取和活动的抑制作用的胆囊收缩素（CCK）受体类型，我们在腹腔注射CCK-8之前，注射了A型CCK受体拮抗剂MK-329或B型CCK受体拮抗剂L-365,260。MK-329逆转了CCK-8的抑制作用，但L-365,260没有。这表明，在此年龄的幼鼠中，腹腔注射CCK-8的抑制作用是由A型而非B型CCK受体介导的。
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