Shanks N, Zalcman S, Zacharko R M, Anisman H
Department of Psychology, Carleton University, Ottawa, Ontario.
Pharmacol Biochem Behav. 1991 Jan;38(1):69-75. doi: 10.1016/0091-3057(91)90591-o.
Exposure to inescapable footshock provoked region-specific alterations of norepinephrine (NE), dopamine (DA) and serotonin (5-HT) activity across six strains of mice (A/J, BALB/cByJ, C3H/HeJ, C57BL/6J, DBA/2J and CD-1). The stressor provoked reductions of hypothalamic NE and increased MHPG accumulation in all strains. In contrast, the effects of the stressor on NE activity in the hippocampus and locus coeruleus varied appreciably across strains. In the mesocortex and nucleus accumbens shock induced an increase of DOPAC accumulation and pronounced reductions of DA in some strains, while in others these variations were less pronounced or entirely absent. Stressor-provoked alterations of 5-HT and 5-HIAA were most evident in the mesocortex. Strain-specific neurochemical alterations following footshock are discussed relative to stressor-induced behavioral disturbances and animal models of depression.
对六种品系的小鼠（A/J、BALB/cByJ、C3H/HeJ、C57BL/6J、DBA/2J和CD-1）施加不可逃避的足部电击会引发去甲肾上腺素（NE）、多巴胺（DA）和5-羟色胺（5-HT）活性的区域特异性改变。应激源在所有品系中均引发下丘脑NE的减少以及3-甲氧基-4-羟基苯乙二醇（MHPG）积累的增加。相比之下，应激源对海马体和蓝斑中NE活性的影响在不同品系间有明显差异。在中皮质和伏隔核中，电击在某些品系中诱导3,4-二羟基苯乙酸（DOPAC）积累增加以及DA显著减少，而在其他品系中这些变化则不那么明显或完全不存在。应激源引发的5-HT和5-羟吲哚乙酸（5-HIAA）改变在中皮质最为明显。足部电击后品系特异性神经化学改变将相对于应激源诱导的行为障碍和抑郁症动物模型进行讨论。
