Shanks N, Griffiths J, Anisman H
Douglas Hospital Research Centre, Montreal, Que, Canada.
Behav Brain Res. 1994 Jul 29;63(1):25-33. doi: 10.1016/0166-4328(94)90047-7.
Stressors increase plasma corticosterone concentrations and the turnover of norepinephrine (NE) and dopamine (DA) in some brain regions. However, appreciable interindividual and interstrain differences exist in this respect. The present investigation assessed the NE and DA changes induced by uncontrollable footshock in the BALB/cByJ and C57BL/6ByJ mice and seven recombinant inbred strains. Stressor exposure indeed provoked strain dependent alterations of plasma corticosterone, hypothalamic and mesocortical NE, as well as mesocortcolimbic DA. The profile of stressor effects in the recombinant strains with respect to the NE alterations, the mesocortical DA changes, as well as plasma corticosterone was commensurate with a polygenic mode of inheritance. The data were related to behavioral changes induced by stressors in these strains of mice, as well as to the contribution of the brain amines to stressor-induced behavioral changes.
应激源会增加血浆皮质酮浓度以及某些脑区去甲肾上腺素（NE）和多巴胺（DA）的周转率。然而，在这方面存在明显的个体间和品系间差异。本研究评估了不可控足部电击在BALB/cByJ和C57BL/6ByJ小鼠以及七个重组近交系中诱导的NE和DA变化。应激源暴露确实引发了血浆皮质酮、下丘脑和中皮质NE以及中皮质边缘DA的品系依赖性改变。重组品系中应激源效应在NE改变、中皮质DA变化以及血浆皮质酮方面的特征与多基因遗传模式相符。这些数据与应激源在这些品系小鼠中诱导的行为变化有关，也与脑胺对应激源诱导的行为变化的贡献有关。
