Zacharko R M, Gilmore W, MacNeil G, Kasian M, Anisman H
Carleton University, Ottawa, Ontario, Canada.
Brain Res. 1990 Nov 19;533(2):353-7. doi: 10.1016/0006-8993(90)91363-l.
Intracranial self-stimulation (ICSS) from the mesocortex was assessed in BALB/cByJ, C57BL/6J and DBA/2J mice immediately, 24 h and again 168 h following stressor application. Stressor exposure failed to influence ICSS performance in C57BL/6J mice, while self-stimulation performance was reduced among BALB/cByJ mice only in the immediate post-stressor interval. In contrast, DBA/2J mice exhibited reduced rates of responding for brain stimulation at each of the post-stressor intervals. The potential contribution of DA alterations to the strain-dependent variations of ICSS performance induced by uncontrollable footshock are discussed.
在施加应激源后即刻、24小时以及168小时，对BALB/cByJ、C57BL/6J和DBA/2J小鼠的中皮质进行颅内自我刺激（ICSS）评估。应激源暴露对C57BL/6J小鼠的ICSS行为没有影响，而仅在应激源施加后的即刻时间段内，BALB/cByJ小鼠的自我刺激行为有所减少。相比之下，DBA/2J小鼠在应激源施加后的各个时间段内，对脑刺激的反应率均降低。文中讨论了多巴胺变化对不可控足部电击诱导的ICSS行为的品系依赖性变化的潜在影响。
