Freed Emily F, Bleichert Franziska, Dutca Laura M, Baserga Susan J
Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA.
Mol Biosyst. 2010 Mar;6(3):481-93. doi: 10.1039/b919670f. Epub 2010 Jan 11.
Ribosomes are vital for cell growth and survival. Until recently, it was believed that mutations in ribosomes or ribosome biogenesis factors would be lethal, due to the essential nature of these complexes. However, in the last few decades, a number of diseases of ribosome biogenesis have been discovered. It remains a challenge in the field to elucidate the molecular mechanisms underlying them.
核糖体对于细胞生长和存活至关重要。直到最近,人们一直认为核糖体或核糖体生物发生因子中的突变会是致命的,因为这些复合物具有不可或缺的性质。然而,在过去几十年里,已经发现了一些核糖体生物发生相关的疾病。阐明其潜在的分子机制仍是该领域的一项挑战。