青年人口腔鳞状细胞癌预后因素的病例对照研究。
Case-control study on prognostic factors in oral squamous cell carcinoma in young patients.
机构信息
Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Hospital, São Paulo, Brazil.
出版信息
Head Neck. 2010 Nov;32(11):1460-6. doi: 10.1002/hed.21347.
BACKGROUND
Oral squamous cell carcinoma affects mainly patients between the fifth and sixth decades of life, being rare in the young (≤40 years old).
METHODS
Demographic, clinical, and pathologic features, and the long-term survival of 125 patients younger than 41 years of age were compared with 250 control patients older than 50 years old. Data were submitted to Kaplan-Meier and log-rank tests.
RESULTS
The percentage of nonsmokers was higher in the younger patients (p = .04). In the younger patients, tumors at advanced clinical stage (p < .01) and poorly differentiated tumors (p = .01) were associated with a higher risk of recurrence. The relapse rate was higher in the younger patients (p = .02); however, there was no significant difference on overall survival (p = .86). The younger patients diagnosed after the 1990s had less advanced clinical stage tumors, had an increase in the use of combination of surgery, radiotherapy, and chemotherapy, and their overall survival was improved.
CONCLUSION
This study emphasizes the importance of early diagnosis and aggressive treatment of oral squamous cell carcinoma.
背景
口腔鳞状细胞癌主要影响 50 至 60 岁之间的患者，在年轻人（≤40 岁）中很少见。
方法
比较了 125 名年龄小于 41 岁的患者与 250 名年龄大于 50 岁的对照组患者的人口统计学、临床和病理特征以及长期生存情况。数据提交给 Kaplan-Meier 和对数秩检验。
结果
年轻患者中不吸烟者的比例更高（p =.04）。在年轻患者中，临床晚期肿瘤（p <.01）和低分化肿瘤（p =.01）与更高的复发风险相关。年轻患者的复发率更高（p =.02）；然而，总体生存率无显著差异（p =.86）。90 年代以后诊断的年轻患者临床分期较晚，手术、放疗和化疗联合应用增加，总体生存率提高。
结论
本研究强调了早期诊断和积极治疗口腔鳞状细胞癌的重要性。
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