Szewczyk Mateusz, Pazdrowski Jakub, Golusiński Paweł, Więckowska Barbara, Golusiński Wojciech
Department of Head and Neck Surgery, Poznań University of Medical Sciences, The Greater Poland Cancer Center, Poznań, Poland.
Department of Otolaryngology and Maxillofacial Surgery, University of Zielona Góra, Zielona Góra, Poland.
Front Oncol. 2024 Apr 5;14:1297752. doi: 10.3389/fonc.2024.1297752. eCollection 2024.
OBJECTIVE: The influence of age on treatment outcomes in oral cancer is unclear. We aimed to determine the prevalence of oral cancer in adults under age 45 and to compare treatment outcomes by age. METHODS: Retrospective study of 284 patients treated for oral cancer from 2010 to 2021. The primary analysis involved the full cohort stratified by age (< vs. ≥ 45y). The second analysis included all patients under age 45 (n=44) matched 1:1 by sex and stage to older patients (age 55-70). RESULTS: In the primary analysis, the only significant difference was more comorbidities in the older group (p<0.001). In the matched-pair analysis, older patients were more likely to be smokers (75% vs. 54%; p=0.045) and had more comorbidities (p=0.007). The mean PLR and NLR values were significantly higher in the younger group. CONCLUSIONS: No significant differences were observed between age groups in disease stage or outcomes, suggesting that other variables are more important.
目的：年龄对口腔癌治疗结果的影响尚不清楚。我们旨在确定45岁以下成年人口腔癌的患病率，并按年龄比较治疗结果。 方法：对2010年至2021年接受口腔癌治疗的284例患者进行回顾性研究。主要分析涉及按年龄（<45岁与≥45岁）分层的全队列。第二项分析包括45岁以下的所有患者（n = 44），这些患者按性别和分期与年龄较大的患者（55 - 70岁）1:1匹配。 结果：在主要分析中，唯一显著的差异是老年组合并症更多（p<0.001）。在配对分析中，老年患者吸烟的可能性更大（75%对54%；p = 0.045）且合并症更多（p = 0.007）。年轻组的平均血小板与淋巴细胞比率（PLR）和中性粒细胞与淋巴细胞比率（NLR）值显著更高。 结论：各年龄组在疾病分期或结果方面未观察到显著差异，这表明其他变量更为重要。
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Crit Rev Oncol Hematol. 2023-10
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