Department of Psychology, University of Georgia, Athens, GA 30602, USA.
J Fam Psychol. 2010 Feb;24(1):12-20. doi: 10.1037/a0018074.
There is a growing body of data indicating that Gene x Child Maltreatment interactions at monoamine oxidase A (MAOA) play a role in vulnerability to symptoms of antisocial personality disorder (ASPD) but not major depression (MD). Using a sample of 538 participants from the Iowa Adoption Studies, we introduce a conceptual model that highlights two distinct pathways from child maltreatment to symptoms of MD, suggesting that maltreatment has different effects depending on genotype and highlighting the importance of including the indirect pathway through ASPD. As predicted by the model, high activity alleles predispose to symptoms of MD in the context of child maltreatment whereas low activity alleles predispose to symptoms of ASPD. We conclude that the Gene x Environment interplay at this locus (MAOA) contributes to both symptoms of ASPD and MD and that careful specification of child maltreatment may be essential if genetic association research is to produce replicable results.
越来越多的数据表明，单胺氧化酶 A（MAOA）基因与儿童虐待的相互作用在易患反社会人格障碍（ASPD）症状但不易患重度抑郁症（MD）方面发挥了作用。我们使用爱荷华收养研究中的 538 名参与者样本，引入了一个概念模型，该模型突出了从儿童虐待到 MD 症状的两种不同途径，表明虐待对不同的基因型有不同的影响，并强调了包括通过 ASPD 的间接途径的重要性。正如该模型所预测的，高活性等位基因易患儿童虐待背景下的 MD 症状，而低活性等位基因易患 ASPD 症状。我们的结论是，该基因座（MAOA）的基因与环境相互作用导致了 ASPD 和 MD 的症状，并且如果遗传关联研究要产生可重复的结果，则仔细说明儿童虐待情况可能至关重要。
