基因组瑰宝：SINE RNA 调控 mRNA 的生成。
Genomic gems: SINE RNAs regulate mRNA production.
机构信息
Department of Chemistry and Biochemistry, University of Colorado, Boulder, 80309-0215, USA.
出版信息
Curr Opin Genet Dev. 2010 Apr;20(2):149-55. doi: 10.1016/j.gde.2010.01.004. Epub 2010 Feb 20.
Mammalian short interspersed elements (SINEs) are abundant retrotransposons that have long been considered junk DNA; however, RNAs transcribed from mouse B2 and human Alu SINEs have recently been found to control mRNA production at multiple levels. Upon cell stress B2 and Alu RNAs bind RNA polymerase II (Pol II) and repress transcription of some protein-encoding genes. Bi-directional transcription of a B2 SINE establishes a boundary that places the growth hormone locus in a permissive chromatin state during mouse development. Alu RNAs embedded in Pol II transcripts can promote evolution and proteome diversity through exonization via alternative splicing. Given the diverse means by which SINE encoded RNAs impact production of mRNAs, this genomic junk is proving to contain hidden gems.
哺乳动物短散在元件（SINEs）是丰富的逆转录转座子，长期以来一直被认为是垃圾 DNA；然而，最近发现从小鼠 B2 和人类 Alu SINE 转录的 RNA 可以在多个层面控制 mRNA 的产生。在细胞应激下，B2 和 Alu RNA 与 RNA 聚合酶 II（Pol II）结合并抑制一些编码蛋白基因的转录。B2 SINE 的双向转录建立了一个边界，在小鼠发育过程中将生长激素基因座置于允许染色质状态。嵌入 Pol II 转录本中的 Alu RNA 可以通过选择性剪接的外显子化促进进化和蛋白质组多样性。鉴于 SINE 编码的 RNA 影响 mRNA 产生的多种方式，这种基因组垃圾正在被证明包含隐藏的瑰宝。
Zotero 插件