Ching F P, Omogbai E K I, Okpo S O, Ozolua R I
Department of Pharmacology, Faculty of Basic Medical Sciences, College of Health Sciences, Niger Delta University, WilberforceIsland, Yenagoa, Bayelsa State, Nigeria.
Indian J Pharm Sci. 2009 Jan;71(1):106-10. doi: 10.4103/0250-474X.51943.
Stereospermum kunthianum, Cham, Sandrine Petit (family: Bignoniaceae) is used in traditional medicine to treat bronchitis, pneumonia and coughs, gastritis, wounds, rheumatic arthritis, ulcers, dysentery, leprosy and venereal diseases in humans. The antiinflammatory activity of the aqueous extract of the stem bark was investigated with experimental animal models using the carrageenan-induced paw oedema, leucocytes migration and granuloma air pouch tests in rats. The extract (100, 200 or 400 mg/kg) at 3 h post-treatment caused a significant (p<0.05) reduction in the paw oedema in rats. The effect of the extract was most pronounced at the dose of 400 mg/kg and was higher than that of indomethacin (10 mg/kg). The extract (400 mg/kg) caused a significant (p<0.05) reduction in the number of recruited leucocytes and it's inhibition of peritoneal exudate formation was comparable to that of indomethacin at a dose of 10 mg/kg. The exudate formation inhibited by 400 mg/kg of the extract in the granuloma air pouch test was comparatively less to that of indomethacin at a dose of 10 mg/kg. The findings of the study indicate that the aqueous extract of Stereospermum kunthianum stem bark possesses antiinflammatory activity which is probably related to the inhibition of prostaglandin synthesis. This is a possible rationale for its folkloric use as an antiinflammatory agent.
昆氏火焰树（学名：Stereospermum kunthianum, Cham），桑德琳·佩蒂特（所属科：紫葳科），在传统医学中用于治疗人类的支气管炎、肺炎和咳嗽、胃炎、伤口、风湿性关节炎、溃疡、痢疾、麻风病和性病。采用角叉菜胶诱导大鼠足肿胀、白细胞迁移和肉芽肿气囊试验等实验动物模型，研究了该植物茎皮水提取物的抗炎活性。给药3小时后，提取物（100、200或400mg/kg）可使大鼠足肿胀显著减轻（p<0.05）。提取物在400mg/kg剂量时效果最为显著，且高于消炎痛（10mg/kg）。提取物（400mg/kg）可使募集的白细胞数量显著减少（p<0.05），其对腹腔渗出物形成的抑制作用与10mg/kg剂量的消炎痛相当。在肉芽肿气囊试验中，400mg/kg提取物对渗出物形成的抑制作用相对低于10mg/kg剂量的消炎痛。该研究结果表明，昆氏火焰树茎皮水提取物具有抗炎活性，这可能与其抑制前列腺素合成有关。这是其在民间用作抗炎剂的一个可能的理论依据。
