一项前瞻性、观察性队列研究，旨在探讨在恰蒂斯加尔邦偏远资源受限的部落人群中抗逆转录病毒药物的不良反应。
A prospective, observational cohort study to elicit adverse effects of antiretroviral agents in a remote resource-restricted tribal population of Chhattisgarh.
机构信息
Department of Pharmacology, Medicine, Anatomy and PSM, Government Medical College, Jagdalpur, Chhattisgarh - 494001, India.
出版信息
Indian J Pharmacol. 2009 Oct;41(5):224-6. doi: 10.4103/0253-7613.58512.
OBJECTIVE
To assess the adverse effects of antiretroviral therapy (HAART) and its adherence in HIV-infected patients, in remote and tribal area with restricted resources.
MATERIALS AND METHODS
This was a prospective, observational study carried out at Department of Medicine, Government Medical College, Jagdalpur. A set of questions were asked and adverse drug reactions (ADRs) were recorded for every patient.
RESULTS
79 HIV positive patients were analyzed. Among them, 68 (86%) had at least one ADR. The mean ADR per patient was 1.64 (+/-1.09). The most common ADR in our study was peripheral neuropathy (20.83%), followed by skin rashes (15.83%). Twenty-one patients (26.58%) had severe (grade-3 and grade-4) ADRs. Female patients had more ADRs (45.71%) than males (11.36%); severe ADRs had a statistically significant positive correlation with sex and CD4 cell count of the patients.
CONCLUSION
In spite of high ADRs, HAART is the only answer to HIV/AIDS; thus, management requires a highly precise balance between benefits of durable HIV suppression and the risks of drug toxicity to achieve the therapeutic goals, with conventional drugs or with newer less toxic agents.
目的
评估在资源有限的偏远和部落地区，接受抗逆转录病毒疗法（HAART）及其依从性对 HIV 感染者的不良影响。
材料与方法
这是在贾格达布尔政府医学院内科进行的一项前瞻性观察性研究。向每位患者提出了一组问题，并记录了药物不良反应（ADR）。
结果
分析了 79 名 HIV 阳性患者。其中，68 名（86%）至少有一种不良反应。每位患者的平均不良反应数为 1.64（+/-1.09）。我们研究中最常见的不良反应是周围神经病（20.83%），其次是皮疹（15.83%）。21 名患者（26.58%）出现严重（3 级和 4 级）不良反应。女性患者的不良反应（45.71%）多于男性（11.36%）；严重不良反应与患者的性别和 CD4 细胞计数呈正相关，具有统计学意义。
结论
尽管不良反应发生率较高，但 HAART 是治疗 HIV/AIDS 的唯一方法；因此，管理需要在持久抑制 HIV 与药物毒性风险之间取得高度精确的平衡，以实现治疗目标，使用常规药物或毒性较小的新型药物。
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