Krupanidhi College of Pharmacy, # 5, Sarjapur Road, Koramongala, Bangalore, India.
Indian J Pharmacol. 2009 Feb;41(1):28-31. doi: 10.4103/0253-7613.48889.
The present study was undertaken to evaluate the anti-stress effect of the hydro-alcoholic extract of clove.
The anti-stress effect was evaluated on cold restraint induced gastric ulcers, sound stress induced biochemical changes and anoxic stress induced convulsions. Clove extract was administered orally at two different doses of 100 and 200 mg/kg. Zeetress, a known anti-stress formulation (14 mg/kg p.o) was used as the standard drug.
Both the doses of clove extract showed good anti-stress effect in all the tested models. The clove extract reduced the development of cold restraint induced gastric ulcers and prevented the biochemical changes induced by sound stress such as increase in plasma levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, glucose, cholesterol and corticosterone. Clove extract was also effective in increasing the latency of anoxic stress induced convulsions in mice.
The hydro-alcoholic extract of clove at doses of 100 and 200 mg/kg orally possesses good anti-stress activity.
本研究旨在评估丁香的水醇提取物的抗应激作用。
通过冷水束缚诱导的胃溃疡、声音应激诱导的生化变化和缺氧应激诱导的惊厥来评估抗应激作用。丁香提取物以 100 和 200mg/kg 的两种不同剂量口服给药。Zeetress（一种已知的抗应激制剂，14mg/kg 口服）被用作标准药物。
丁香提取物的两种剂量在所有测试模型中均显示出良好的抗应激作用。丁香提取物可减少冷水束缚诱导的胃溃疡的发展，并防止声音应激引起的生化变化，如血浆中天冬氨酸氨基转移酶、丙氨酸氨基转移酶、碱性磷酸酶、葡萄糖、胆固醇和皮质酮水平的升高。丁香提取物还可有效延长缺氧应激诱导的惊厥潜伏期。
丁香的水醇提取物在 100 和 200mg/kg 的剂量下口服具有良好的抗应激活性。
