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An uncommon paraneoplastic Ri-positive opsoclonus-myoclonus-like syndrome and stiff-person syndrome with elevated glutamate/GABA ratio in the cerebrospinal fluid after breast cancer.

作者信息

Thümen A, Moser A

出版信息

J Neurol. 2010 Jul;257(7):1215-7. doi: 10.1007/s00415-010-5501-z. Epub 2010 Feb 23.

DOI:10.1007/s00415-010-5501-z
PMID:20177693
Abstract
摘要

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1
An uncommon paraneoplastic Ri-positive opsoclonus-myoclonus-like syndrome and stiff-person syndrome with elevated glutamate/GABA ratio in the cerebrospinal fluid after breast cancer.一种罕见的副肿瘤性Ri阳性眼阵挛-肌阵挛样综合征及僵人综合征，发生于乳腺癌后，脑脊液中谷氨酸/γ-氨基丁酸比值升高。
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2
Antibody-phenotype correlation in stiff-person syndrome.僵人综合征中的抗体-表型相关性
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3
Autoantibodies to a 128-kd synaptic protein in three women with the stiff-man syndrome and breast cancer.三名患有僵人综合征和乳腺癌的女性体内针对一种128-kd突触蛋白的自身抗体。
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Opsoclonus-myoclonus syndrome in anti-N-methyl-D-aspartate receptor encephalitis.抗N-甲基-D-天冬氨酸受体脑炎中的眼阵挛-肌阵挛综合征
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Anti-Ri antibody opsoclonus-myoclonus syndrome and breast cancer: a case report and a review of the literature.抗Ri抗体相关的眼阵挛-肌阵挛综合征与乳腺癌：一例病例报告及文献综述
J Surg Oncol. 2004 Sep 1;87(3):143-5. doi: 10.1002/jso.20103.
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Paraneoplastic stiff-person syndrome: no tumor progression over 5 years.
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Inhibition of gamma-aminobutyric acid synthesis by glutamic acid decarboxylase autoantibodies in stiff-man syndrome.僵人综合征中谷氨酸脱羧酶自身抗体对γ-氨基丁酸合成的抑制作用。
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Efficacy and safety of therapeutic plasma exchange in stiff person syndrome.治疗性血浆置换在僵人综合征中的疗效与安全性。
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Clinical spectrum and diagnostic pitfalls of neurologic syndromes with Ri antibodies.

本文引用的文献

1
GABA(A) autoreceptors enhance GABA release from human neocortex: towards a mechanism for high-frequency stimulation (HFS) in brain?GABA(A)自身受体增强人新皮质中GABA的释放：脑内高频刺激（HFS）机制的研究方向？
Naunyn Schmiedebergs Arch Pharmacol. 2009 Jul;380(1):45-58. doi: 10.1007/s00210-009-0410-3. Epub 2009 Mar 19.
2
Progressive encephalomyelitis, rigidity, and myoclonus: a novel glycine receptor antibody.进行性脑脊髓炎、强直和肌阵挛：一种新型甘氨酸受体抗体
Neurology. 2008 Oct 14;71(16):1291-2. doi: 10.1212/01.wnl.0000327606.50322.f0.
3
Paraneoplastic syndromes affecting the nervous system.
伴有 Ri 抗体的神经综合征的临床谱和诊断陷阱。
Neurol Neuroimmunol Neuroinflamm. 2020 Mar 13;7(3). doi: 10.1212/NXI.0000000000000699. Print 2020 May.
4
Paraneoplastic neurological complications of breast cancer.乳腺癌的副肿瘤性神经并发症
Exp Hematol Oncol. 2016 Oct 24;5:29. doi: 10.1186/s40164-016-0058-x. eCollection 2015.
5
Anti-glutamic acid decarboxylase antibody positive neurological syndromes.抗谷氨酸脱羧酶抗体阳性神经系统综合征
Neurosciences (Riyadh). 2016 Jul;21(3):215-22. doi: 10.17712/nsj.2016.3.20150596.
6
Clinical Spectrum of Stiff Person Syndrome: A Review of Recent Reports.僵人综合征的临床谱：近期报告综述
Tremor Other Hyperkinet Mov (N Y). 2016 Mar 4;6:340. doi: 10.7916/D85M65GD. eCollection 2016.
7
A case of glycine-receptor antibody-associated encephalomyelitis with rigidity and myoclonus (PERM): clinical course, treatment and CSF findings.一例伴有僵硬和肌阵挛的甘氨酸受体抗体相关脑脊髓炎（PERM）：临床病程、治疗及脑脊液检查结果
J Neurol. 2011 Dec;258(12):2268-70. doi: 10.1007/s00415-011-6078-x. Epub 2011 May 4.
影响神经系统的副肿瘤综合征。
Semin Oncol. 2006 Jun;33(3):270-98. doi: 10.1053/j.seminoncol.2006.03.008.
4
Analysis of GAD65 autoantibodies in Stiff-Person syndrome patients.僵人综合征患者中谷氨酸脱羧酶65自身抗体的分析。
J Immunol. 2005 Dec 1;175(11):7755-62. doi: 10.4049/jimmunol.175.11.7755.
5
Brain gamma-aminobutyric acid changes in stiff-person syndrome.僵人综合征患者大脑中γ-氨基丁酸的变化
Arch Neurol. 2005 Jun;62(6):970-4. doi: 10.1001/archneur.62.6.970.
6
Markedly elevated GAD antibodies in SPS: effects of age and illness duration.僵人综合征中谷氨酸脱羧酶抗体显著升高：年龄和病程的影响
Neurology. 2004 Dec 14;63(11):2146-8. doi: 10.1212/01.wnl.0000145661.01675.a8.
7
Recommended diagnostic criteria for paraneoplastic neurological syndromes.副肿瘤性神经系统综合征的推荐诊断标准。
J Neurol Neurosurg Psychiatry. 2004 Aug;75(8):1135-40. doi: 10.1136/jnnp.2003.034447.
8
Paraneoplastic "stiff person syndrome" with metastatic adenocarcinoma and anti-Ri antibodies.伴转移性腺癌及抗Ri抗体的副肿瘤性“僵人综合征”
Neurology. 2004 Apr 27;62(8):1402-4. doi: 10.1212/01.wnl.0000123694.64121.d5.
9
Motor cortex excitability in stiff-person syndrome.僵人综合征中的运动皮质兴奋性
Brain. 2000 Nov;123 ( Pt 11):2231-9. doi: 10.1093/brain/123.11.2231.
10
Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system.副肿瘤性Ri抗原Nova与一种RNA结合蛋白同源，且在发育中的运动系统中特异性表达。
Neuron. 1993 Oct;11(4):657-72. doi: 10.1016/0896-6273(93)90077-5.