Franz-Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany.
Horm Metab Res. 2010 May;42(5):334-9. doi: 10.1055/s-0030-1248250. Epub 2010 Feb 22.
Atrial natriuretic peptide (ANP) stimulates lipid mobilization and lipid oxidation in humans. The mechanism appears to promote lipid mobilization during exercise. We tested the hypothesis that water immersion augments exercise-induced ANP release and that the change in ANP availability is associated with increased lipid mobilization and lipid oxidation. In an open randomized and cross-over fashion we studied 17 men (age 31+/-3.6 years; body mass index 24+/-1.7 kg/m(2); body fat 17+/-6.7%) on no medication. Subjects underwent two incremental exercise tests on a bicycle ergometer. One test was conducted on land and the other test during immersion in water up to the xiphoid process. In a subset (n=7), we obtained electromyography recordings in the left leg. We monitored gas exchange, blood pressure, and heart rate. In addition, we obtained blood samples towards the end of each exercise step to determine ANP, norepinephrine, epinephrine, lactate, free fatty acids, insulin, and glucose concentrations. Heart rate, systolic blood pressure, and oxygen consumption at the anaerobic threshold and during peak exercise were similar on land and with exercise in water. The respiratory quotient was mildly reduced when subjects exercised in water. Glucose and lactate measurements were decreased whereas free fatty acid concentrations were increased with exercise in water. Water immersion attenuated epinephrine and norepinephrine and augmented ANP release during exercise. Even though water immersion blunts exercise-induced sympathoadrenal activation, lipid mobilization and lipid oxidation rate are maintained or even improved. The response may be explained by augmented ANP release.
心房利钠肽 (ANP) 可刺激人体的脂质动员和氧化。其机制似乎可促进运动过程中的脂质动员。我们检验了这样一个假设，即浸水会增强运动诱导的 ANP 释放，而 ANP 供应的变化与增加的脂质动员和脂质氧化有关。我们以开放、随机和交叉的方式研究了 17 名男性（年龄 31+/-3.6 岁；体重指数 24+/-1.7kg/m(2)；体脂 17+/-6.7%），他们没有服用任何药物。受试者在自行车测力计上进行了两次递增运动测试。一次在陆地上进行，另一次在浸入水中直至剑突的测试中进行。在一组（n=7）中，我们在左腿上获得了肌电图记录。我们监测了气体交换、血压和心率。此外，我们在每个运动阶段结束时获得了血液样本，以确定 ANP、去甲肾上腺素、肾上腺素、乳酸、游离脂肪酸、胰岛素和血糖浓度。陆地和水中运动时的心率、收缩压和无氧阈及峰值运动时的耗氧量相似。当受试者在水中运动时，呼吸商略有降低。葡萄糖和乳酸测量值降低，而游离脂肪酸浓度升高。水浸会在运动过程中减弱肾上腺素和去甲肾上腺素的作用，并增强 ANP 的释放。尽管水浸会削弱运动引起的交感神经激活，但脂质动员和脂质氧化率保持或甚至改善。这种反应可能是由于 ANP 释放增加所致。
