Department of Medicine I, University of Erlangen-Nuremberg, 91054 Erlangen, Germany.
Endoscopy. 2010 Apr;42(4):334-7. doi: 10.1055/s-0029-1243936. Epub 2010 Feb 22.
Lymphoid hyperplasia of the intestine has been associated with multiple diseases and symptoms. This study was undertaken to analyze the number and topographical distribution of the lymphoid follicles. A total of 302 adult consecutive patients were enrolled when they underwent elective colonoscopy. Standardized pictures from terminal ileum and colon were taken using video colonoscopes. In each picture, the number, size, and mucosal elevation of lymphoid follicles were analyzed in relation to histological and immunological findings and medical history. Lymphoid hyperplasia was found to be most extensive in the terminal ileum and cecum. Patients with untreated gastrointestinally mediated allergy (GMA) showed the highest number of lymphoid follicles per visible field in the terminal ileum ( P < 0.001) and cecum ( P = 0.003) vs. the control group. Patients with infectious colitis also showed a high number of lymphoid follicles per endoscopic visible field in the transverse colon ( P = 0.020). The presence of lymphoid hyperplasia is a frequent finding during colonoscopy. It may indicate an enhanced immunological mucosal response to antigenic stimulation such as GMA or infection.
肠淋巴组织增生与多种疾病和症状有关。本研究旨在分析肠黏膜固有层淋巴滤泡的数量和分布。对 302 例行择期结肠镜检查的成年连续患者进行了研究。使用视频结肠镜采集末端回肠和结肠的标准图像。根据组织学和免疫学发现以及病史，分析了每张图片中淋巴滤泡的数量、大小和黏膜隆起。肠淋巴组织增生在末端回肠和盲肠最为广泛。未经治疗的胃肠道介导过敏（GMA）患者在末端回肠（P < 0.001）和盲肠（P = 0.003）的每个可见视野中显示出最高数量的淋巴滤泡，与对照组相比。感染性结肠炎患者的横结肠内镜下可见视野中也有大量淋巴滤泡（P = 0.020）。在结肠镜检查中，肠淋巴组织增生是一种常见的发现。它可能表明对 GMA 或感染等抗原刺激的免疫黏膜反应增强。
