Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045, USA.
Org Lett. 2010 Mar 19;12(6):1216-9. doi: 10.1021/ol100035e.
A formal [4+3] epoxide cascade protocol utilizing ambiphilic sulfonamides and a variety of epoxides (masked ambiphiles) has been developed for the generation of benzothiaoxazepine-1,1'-dioxides and oxathiazepine-1,1'-dioxides. This protocol combines an epoxide ring-opening with either an S(N)Ar or oxa-Michael cyclization pathway.
已开发出一种利用双亲性磺酰胺和各种环氧化物(掩蔽双亲体)的正式[4+3]环氧化合物级联协议,用于生成苯并噻嗪-1,1'-二氧化物和氧杂噻嗪-1,1'-二氧化物。该协议将环氧化物开环与 S(N)Ar 或氧杂-Michael 环化途径相结合。