Handschin Christoph
Biozentrum, Division of Pharmacology/Neurobiology, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland.
J Recept Signal Transduct Res. 2010 Dec;30(6):376-84. doi: 10.3109/10799891003641074. Epub 2010 Feb 24.
Exercise triggers a pleiotropic response in skeletal muscle, which results in a profound remodeling of this tissue. Physical activity-dependent muscle fiber plasticity is regulated by a number of distinct signaling pathways. Even though most of these pathways are activated by different stimuli and in a temporally and spatially separated manner during exercise, many of the major signal transduction events converge on the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) by post-translationally modifying the PGC-1α protein, modulating PGC-1α gene expression or both. In turn, depending on the cellular context, PGC-1α regulates specific gene programs. Ultimately, PGC-1α modulates most of the transcriptional adaptations of skeletal muscle to exercise. In this review, the regulation and function of this pivotal transcriptional coactivator in muscle are discussed.
运动引发骨骼肌的多效性反应，导致该组织发生深刻重塑。身体活动依赖的肌纤维可塑性受多种不同信号通路调控。尽管这些通路中的大多数在运动过程中由不同刺激以时空分离的方式激活，但许多主要信号转导事件通过对过氧化物酶体增殖物激活受体γ共激活因子1α（PGC-1α）进行翻译后修饰、调节PGC-1α基因表达或两者兼而有之，从而汇聚到PGC-1α上。反过来，根据细胞环境，PGC-1α调节特定的基因程序。最终，PGC-1α调节骨骼肌对运动的大部分转录适应性变化。在本综述中，将讨论这种关键转录共激活因子在肌肉中的调控及功能。
