Biomedical Research Institute, Kyungpook National University Hospital, 50 Samduk 2ga Jung-gu, Daegu 41944, Korea.
QBM Co., Ltd., Seoul 06752, Korea.
Mar Drugs. 2019 Oct 27;17(11):611. doi: 10.3390/md17110611.
Metabolic disorders such as diabetes and obesity are serious global health issues. These diseases are accelerated by mineral deficiencies, emphasizing the importance of addressing these deficiencies in disease management plans. Lactate metabolism is fundamentally linked to glucose metabolism, and several clinical studies have reported that blood lactate levels are higher in obese and diabetic patients than in healthy subjects. Balanced deep-sea water contains various minerals and exhibits antiobesity and antidiabetic activities in mice; however, the impact of balanced deep-sea water on lactate metabolism is unclear. Thus, we evaluated the effects of balanced deep-sea water on lactate metabolism in C2C12 myotubes, and found that balanced deep-sea water mediated lactate metabolism by regulating the gene expression levels of lactate dehydrogenases A and B, a monocarboxylate transporter, and a mitochondrial pyruvate carrier. The activities of peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) and signaling molecules involved in PGC-1α activation were also upregulated by treatment with balanced deep-sea water. These results suggest that balanced deep-sea water, which can mediate lactate metabolism, may be used to prevent or treat obesity and diabetes mellitus.
代谢紊乱疾病，如糖尿病和肥胖症，是全球性的严重健康问题。这些疾病因矿物质缺乏而加速，这强调了在疾病管理计划中解决这些缺乏问题的重要性。乳酸代谢与葡萄糖代谢密切相关，多项临床研究报告称，肥胖和糖尿病患者的血液乳酸水平高于健康受试者。平衡深海水中含有多种矿物质，在小鼠中表现出抗肥胖和抗糖尿病活性；然而，平衡深海水对乳酸代谢的影响尚不清楚。因此，我们评估了平衡深海水对 C2C12 肌管中乳酸代谢的影响，发现平衡深海水通过调节乳酸脱氢酶 A 和 B、单羧酸转运蛋白和线粒体丙酮酸载体的基因表达水平来介导乳酸代谢。过氧化物酶体增殖物激活受体γ共激活因子-1α（PGC-1α）的活性和参与 PGC-1α 激活的信号分子也被平衡深海水的处理上调。这些结果表明，平衡深海水可以调节乳酸代谢，可能用于预防或治疗肥胖症和糖尿病。
