母源到合子过渡的翻译后调控。
Post-translational regulation of the maternal-to-zygotic transition.
机构信息
State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing, 100101, People's Republic of China.
College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
出版信息
Cell Mol Life Sci. 2018 May;75(10):1707-1722. doi: 10.1007/s00018-018-2750-y. Epub 2018 Feb 9.
Abstract
The maternal-to-zygotic transition (MZT) is essential for the developmental control handed from maternal products to newly synthesized zygotic genome in the earliest stages of embryogenesis, including maternal component (mRNAs and proteins) degradation and zygotic genome activation (ZGA). Various protein post-translational modifications have been identified during the MZT, such as phosphorylation, methylation and ubiquitination. Precise post-translational regulation mechanisms are essential for the timely transition of early embryonic development. In this review, we summarize recent progress regarding the molecular mechanisms underlying post-translational regulation of maternal component degradation and ZGA during the MZT and discuss some important issues in the field.
摘要
母源到合子的转变（MZT）对于胚胎发生早期从母体产物到新合成的合子基因组的发育控制至关重要，包括母体成分（mRNA 和蛋白质）的降解和合子基因组激活（ZGA）。在 MZT 期间已经鉴定出各种蛋白质翻译后修饰，如磷酸化、甲基化和泛素化。精确的翻译后调控机制对于早期胚胎发育的适时转变至关重要。在这篇综述中，我们总结了 MZT 期间母体成分降解和 ZGA 的翻译后调控的分子机制的最新进展，并讨论了该领域的一些重要问题。
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