The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Curr Opin Clin Nutr Metab Care. 2010 May;13(3):294-9. doi: 10.1097/MCO.0b013e328337d7b9.
This review is an update on recent findings regarding early growth patterns and later obesity. These data are important because the potential programming of obesity in early life provides hope for new prevention strategies targeting early growth for long-term benefits.
Recent findings regarding the association of childhood or adulthood obesity with fetal growth, gestational weight gain, maternal diabetes, or infancy weight gain are reviewed. Some related outcomes and potential mechanisms are also described. Most studies remain observational and confirm previous findings, but some intervention studies have begun to appear in the recent literature and support some, but not other, observed associations.
Past and recent findings confirm the association of early growth patterns with obesity. However, causality must be demonstrated and safety must be established before translating these findings into public health recommendations.
本综述更新了有关早期生长模式与后期肥胖的最新发现。这些数据很重要，因为生命早期肥胖的潜在编程为针对早期生长的长期获益的新预防策略提供了希望。
综述了儿童期或成年期肥胖与胎儿生长、妊娠期体重增加、母亲糖尿病或婴儿期体重增加的关联的最新发现。还描述了一些相关的结果和潜在的机制。大多数研究仍然是观察性的，证实了以前的发现，但一些干预研究最近开始出现在文献中，支持一些，但不是其他的观察到的关联。
过去和最近的发现证实了早期生长模式与肥胖之间的关联。然而，在将这些发现转化为公共卫生建议之前，必须证明因果关系并确保安全性。
