Department of Radiotherapy, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.
Curr Oncol. 2010 Feb;17(1):64-9. doi: 10.3747/co.v17i1.451.
Here we report a case of primary epithelioid angiosarcoma (eas) of the breast occurring in a 30-year-old woman. Following fine-needle asspiration cytology (fnac) and tru-cut biopsy, the patient was initially diagnosed with mammary carcinoma and thereafter underwent modified radical mastectomy. Postoperative histopathologic examination and immunohistochemistry revealed a diagnosis of primary epithelioid angiosarcoma of the breast. The patient received postoperative radiotherapy to the chest wall and was started on adjuvant thalidomide. Preoperatively, eas can be mistaken for carcinoma because it is difficult to appreciate the typical morphology on fnac or tru-cut biopsy. Indeed, this is an area of potential diagnostic error because, nowadays, neoadjuvant therapy is often instituted after core biopsy of a breast mass. This case is being reported not only for its diagnostic difficulty, but also because of its rarity in English literature.
我们在此报告一例发生于 30 岁女性的原发性上皮样血管肉瘤（EAS）。在细针抽吸细胞学检查（FNAC）和 tru-cut 活检后，患者最初被诊断为乳腺癌，随后接受了改良根治性乳房切除术。术后组织病理学检查和免疫组织化学检查显示为原发性乳腺上皮样血管肉瘤的诊断。患者接受了胸壁术后放疗，并开始接受辅助沙利度胺治疗。在术前，EAS 可能被误诊为癌，因为在 FNAC 或 tru-cut 活检上很难观察到典型形态。事实上，这是一个潜在的诊断错误领域，因为现在，在乳房肿块的核心活检后，经常会进行新辅助治疗。本病例不仅因其诊断困难而报告，还因其在英文文献中的罕见性而报告。
