Macías-Martínez V, Murrieta-Tiburcio L, Molina-Cárdenas H, Domínguez-Malagón H
Department of Surgical Pathology, Instituto Nacional de Cancerología, Mexico City, Mexico.
Am J Surg Pathol. 1997 May;21(5):599-604. doi: 10.1097/00000478-199705000-00014.
A breast tumor with features of epithelioid angiosarcoma (EAS) occurring in a 26-year-old woman is described. The lesion on lumpectomy was initially diagnosed as infiltrating ductal carcinoma and treated accordingly by radical mastectomy. The surgical specimen disclosed a high-grade tumor characterized by solid groups and sheets of atypical polygonal epithelioid cells displaying cytoplasmic microlumina alternating with anastomosing vascular channels. The endothelial nature of the epithelioid cells was demonstrated by the presence of vascular endothelium-associated markers by immunohistochemical and ultrastructural studies. The clinical features of this rare, hitherto undescribed lesion are similar to those of conventional breast angiosarcoma. The recognition of this entity is crucial because it can be confused with neoplasms displaying epithelial cytomorphology such as ductal carcinoma, pseudoangiosarcomatous carcinoma, metaplastic carcinoma, and epithelioid hemangioendothelioma. EAS should be added to the list of conditions that may present as a discrete tumor mass of the breast in young women.
本文描述了一名26岁女性发生的具有上皮样血管肉瘤（EAS）特征的乳腺肿瘤。肿块切除术后的病变最初被诊断为浸润性导管癌，并相应地接受了根治性乳房切除术。手术标本显示为高级别肿瘤，其特征为实性细胞团和片状非典型多边形上皮样细胞，细胞质内可见微管腔，与吻合的血管通道交替存在。免疫组织化学和超微结构研究显示上皮样细胞存在血管内皮相关标志物，证实了其内皮性质。这种罕见的、此前未描述过的病变的临床特征与传统乳腺血管肉瘤相似。认识到这一实体至关重要，因为它可能与表现出上皮细胞形态的肿瘤如导管癌、假血管肉瘤样癌、化生性癌和上皮样血管内皮瘤相混淆。EAS应被列入可能表现为年轻女性乳腺离散肿瘤肿块的疾病清单中。
