Institute of Keshan Disease, Harbin Medical University, No. 157 Baojian Road, Harbin 150081 Heilongjiang, China.
Biol Trace Elem Res. 2010 Dec;138(1-3):53-9. doi: 10.1007/s12011-010-8609-1. Epub 2010 Feb 24.
Selenium deficiency is widely accepted as a fundamental cause of Keshan disease (KD). In the present study, the selenium levels of hair and food samples of KD in some endemic areas were measured; the prevalence and incidence of KD for the year 2007 in these areas were surveyed. The results for KD surveillance from 2003 to 2007 were analyzed. The selenium level was measured fluorometrically. In 2007, a total of 19,280 residents were surveyed in 15 provinces. The prevalence and incidence of KD were 3.0% and 4.9‰, respectively. In KD and control subjects, the mean levels of hair selenium were respectively 0.3223 mg/kg and 0.4466 mg/kg. The mean level of staple food selenium was 0.0227 ± 0.0144 mg/kg. During the 5 years, the selenium content in hair was always kept at a normal level within inhabitants of KD-endemic areas, but that in staple food was always kept at a lower level. These results indicate that the pathogenic factor has not been drastically eliminated even with the increasing selenium level of internal environment and is still continually damaging public health of KD in endemic areas. Since KD is still a serious threat to public health in its endemic areas, it is of great importance to pay attention to the prevention and control of this disease.
硒缺乏被广泛认为是克山病（KD）的根本原因。本研究对部分病区居民发硒和食物硒进行了检测，并对这些地区 2007 年克山病的发病、患病情况进行了调查，同时对 2003 年至 2007 年的克山病监测资料进行了分析。采用荧光分光光度法进行硒测定。2007 年在 15 个省共调查了 19 280 人，克山病的患病率和发病率分别为 3.0%和 4.9‰。克山病组和对照组发硒均值分别为 0.3223mg/kg 和 0.4466mg/kg，主食硒均值分别为 0.0227±0.0144mg/kg。5 年来病区居民发硒始终处于正常水平，而主食硒一直处于较低水平。这表明，尽管内环境硒含量不断增加，但致病因素并未得到根本消除，仍在持续损害病区居民的健康。由于克山病仍是病区严重的公共卫生问题，因此，关注克山病的防治工作具有重要意义。
