Zou Yuanjie, Liu Xu, Wang Tong, Wang Yanan, Han Shan, Zhang Yiyi, Su Shengqi, Zhou Huihui, Zhang Xiao, Liang Hong, Jia Yuehui, Qi Lei, Wang Yuanyuan, Wang Ruixiang
Institute of Keshan Disease, Chinese Center for Endemic Disease Control, Harbin Medical University, 157 Baojian Road, Harbin, 150081, China.
Infectious Disease Hospital of Heilongjiang Province, Harbin, China.
Biol Trace Elem Res. 2021 Dec;199(12):4546-4554. doi: 10.1007/s12011-021-02609-1. Epub 2021 Feb 3.
This study was aimed to provide, by mapping the spatial distribution of hair selenium levels of residents, visualized evidence for assessment of KD elimination from a perspective of selenium nutrition of the residents living in the KD-endemic and non-endemic areas. Using a spatial ecological research design, 401 male permanent residents in KD-endemic and non-endemic areas participated in this study. Demographic information and hair samples were obtained through a questionnaire survey and sample collection, respectively. Hair selenium was measured using hydride generation atomic fluorescence spectrometry. Thematic maps were created, and spatial analysis was conducted using ArcGIS 9.0. The median of hair selenium of the participants was 0.30 (IQR, 0.23-0.34) mg/kg. The median hair selenium of the residents in the KD-endemic areas was significantly lower than that of the residents of the non-endemic areas. The hair selenium levels of residents were spatially clustered, with cold spots and hot spots located in northwest and southwest regions respectively. Residents living in KD-endemic areas may still have selenium deficiency. Measuring hair selenium levels of residents in KD-endemic areas as a molecular marker of selenium nutritional status as part of KD surveillance could provide visualized evidence for the evaluation of KD elimination from a perspective of selenium nutrition of the residents living in the KD endemic areas.
本研究旨在通过绘制居民发硒水平的空间分布，从克山病（KD）病区和非病区居民硒营养的角度，为评估克山病消除情况提供可视化证据。采用空间生态学研究设计，KD病区和非病区的401名男性常住居民参与了本研究。分别通过问卷调查和样本采集获取人口统计学信息和头发样本。采用氢化物发生原子荧光光谱法测定头发硒含量。绘制专题地图，并使用ArcGIS 9.0进行空间分析。参与者的头发硒中位数为0.30（四分位间距，0.23 - 0.34）mg/kg。KD病区居民的头发硒中位数显著低于非病区居民。居民的头发硒水平在空间上呈聚集分布，冷点和热点分别位于西北地区和西南地区。生活在KD病区的居民可能仍存在硒缺乏。将KD病区居民的头发硒水平作为硒营养状况的分子标志物进行测量，作为KD监测的一部分，可从KD病区居民硒营养的角度为评估KD消除情况提供可视化证据。
