Medeiros Marta, Oshima Celina Tizuko Fujiyama, Forones Nora Manoukian
Oncology Division, Gastroenterology Department, Universidade Federal de São Paulo, São Paulo, Brazil.
J Gastrointest Cancer. 2010 Sep;41(3):179-84. doi: 10.1007/s12029-010-9132-5.
Cancer has been seen negatively by the people that disclose fear and anxiety face to the disease closely associated with distress, aggressive treatments, and death. Colorectal cancer is one of the most prevalent cancer and few assays were developed studying depression and anxiety in patients after surgical resection of tumor and before adjuvant therapy.
This research aims to study the prevalence of depression and anxiety in patients with colorectal cancer before and after adjuvant chemotherapy.
After surgical resection of colorectal cancer, 37 patients were included according to the kind of treatment: chemotherapy group (CHG) and the other one without indication of chemotherapy, the control group (CG). Questionnaires of Depression and Anxiety were done at the beginning and at the end of the treatment in the CHG (n = 19) and at the first and after 6 months of follow-up (n = 18) in the CG.
No difference on gender, age, or site was observed among the groups. Stage III tumor was more frequent in the CHG group. Mild or moderate depression was diagnosed in 31.6% of the CHG patients in the first evaluation and in 38.6% at the second one. In the CG no depression was observed in both evaluations. About the State-Trait Anxiety Inventory, the results were similar before and after chemotherapy treatment. There was a higher number of patients with moderate state or trait anxiety in the CHG when compared to the CG in both evaluations. No correlation was found about the inventories of anxiety and depression and site of tumor or stage.
After surgical treatment of colorectal cancer, depression and indexes of anxiety were higher in the group of patients treated with chemotherapy when compared to the control group.
癌症一直被那些直面与痛苦、激进治疗和死亡密切相关疾病的人视为负面事物。结直肠癌是最常见的癌症之一，针对肿瘤手术切除后及辅助治疗前患者的抑郁和焦虑情况，相关研究较少。
本研究旨在探讨结直肠癌患者辅助化疗前后抑郁和焦虑的患病率。
结直肠癌手术切除后，根据治疗方式纳入37例患者：化疗组（CHG）和未进行化疗的对照组（CG）。对CHG组（n = 19）在治疗开始和结束时进行抑郁和焦虑问卷调查，对CG组（n = 18）在随访第1个月和6个月后进行调查。
各组在性别、年龄或肿瘤部位方面无差异。CHG组III期肿瘤更为常见。在首次评估中，31.6%的CHG患者被诊断为轻度或中度抑郁，第二次评估时这一比例为38.6%。CG组在两次评估中均未发现抑郁患者。关于状态-特质焦虑量表，化疗前后结果相似。在两次评估中，CHG组中度状态或特质焦虑患者数量均高于CG组。焦虑和抑郁量表与肿瘤部位或分期之间未发现相关性。
与对照组相比，结直肠癌手术治疗后，化疗组患者的抑郁和焦虑指标更高。
