分开抚养和共同抚养的双胞胎中的特应性疾病与免疫球蛋白E
Atopic disease and immunoglobulin E in twins reared apart and together.
作者信息
Hanson B, McGue M, Roitman-Johnson B, Segal N L, Bouchard T J, Blumenthal M N
机构信息
University of Minnesota Hospital, Minneapolis 55455.
出版信息
Am J Hum Genet. 1991 May;48(5):873-9.
Abstract
Both genetic and environmental influences have been implicated in the etiology of atopic disease and in the determination of serum IgE levels. To quantify the relative contribution of these influences, we studied the prevalence of asthma and seasonal rhinitis, skin-test response, total serum IgE levels, and specific IgE, as measured by RAST, in a sample of MZ and DZ twins reared apart or together. Concordance rates for asthma, rhinitis, positive skin tests, and RAST were calculated. MZ twins, whether reared apart or together, showed a greater concordance than dizygotic twins reared apart or together. Maximum-likelihood tests of genetic and environmental components of the variation of total IgE levels revealed a substantial genetic component and a negligible contribution from common familial environmental effects.
摘要
遗传和环境因素都与特应性疾病的病因及血清IgE水平的决定有关。为了量化这些因素的相对作用，我们对分开抚养或共同抚养的同卵双胞胎（MZ）和异卵双胞胎（DZ）样本进行了研究，观察哮喘和季节性鼻炎的患病率、皮肤试验反应、血清总IgE水平以及通过放射变应原吸附试验（RAST）测定的特异性IgE。计算了哮喘、鼻炎、阳性皮肤试验和RAST的一致率。同卵双胞胎，无论分开抚养还是共同抚养，其一致率均高于分开抚养或共同抚养的异卵双胞胎。对总IgE水平变异的遗传和环境成分进行的最大似然检验显示，存在显著的遗传成分，而常见的家族环境效应贡献可忽略不计。
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