分开抚养的双胞胎中免疫球蛋白和特异性抗体水平的遗传调控。
Genetic regulation of immunoglobulin and specific antibody levels in twins reared apart.
作者信息
Kohler P F, Rivera V J, Eckert E D, Bouchard T J, Heston L L
出版信息
J Clin Invest. 1985 Mar;75(3):883-8. doi: 10.1172/JCI111787.
Abstract
We studied the effect of the same genetic but different environmental factors on total immunoglobulin and specific antibody levels in twins reared apart. Sera were analyzed from 26 monozygotic (MZ) and 10 dizygotic (DZ) twin pairs, who were separated on average 2 mo after birth and reared apart. Total IgM, IgG, and IgA were measured by single radial diffusion. Specific antibodies of each isotype to tetanus toxoid, and to polyvalent and type 14 pneumococcal capsular polysaccharides were measured by a solid-phase antigen-enzyme-labeled anti-Ig immunoassay. One-way analysis of variance showed intrapair total Ig and antibody levels to be more highly correlated in MZ compared with DZ twins. Our results indicate that genetic factors are more important than environment in regulating these humoral immune responses.
摘要
我们研究了相同基因但不同环境因素对分开抚养的双胞胎总免疫球蛋白和特异性抗体水平的影响。分析了26对单卵双胞胎（MZ）和10对双卵双胞胎（DZ）的血清，这些双胞胎平均在出生后2个月分开并在不同环境中抚养。通过单向辐射扩散法测定总IgM、IgG和IgA。通过固相抗原 - 酶标记抗Ig免疫测定法测量每种同型针对破伤风类毒素、多价和14型肺炎球菌荚膜多糖的特异性抗体。单因素方差分析表明，与DZ双胞胎相比，MZ双胞胎中配对内总Ig和抗体水平的相关性更高。我们的结果表明，在调节这些体液免疫反应中，遗传因素比环境因素更重要。
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