招募患有精神和物质使用障碍的青少年参加临床试验的方法。
Methods of recruiting adolescents with psychiatric and substance use disorders for a clinical trial.
机构信息
Mclean Hospital, Harvard Medical School, Massachusetts, USA.
出版信息
Am J Drug Alcohol Abuse. 2009;35(5):381-4. doi: 10.1080/00952990903150860.
Abstract
BACKGROUND
The present article reports on recruiting strategies in a 16-week, multi-site trial of osmotic-release methylphenidate combined with cognitive-behavioral therapy in adolescents with co-occurring attention deficit hyperactivity disorder and substance use disorder.
METHODS
A multifaceted recruiting strategy was employed that targeted multiple referral sources, used incentives, involved numerous staff members, emphasized the therapeutic alliance during prescreening, and utilized data to modify strategies based on results. Overall, 303 adolescents were randomized from 1,333 total referrals across 11 participating sites.
RESULTS
Overall, existing treatment program sources, including treatment program staff, social services, the juvenile justice system, and mental health clinics provided a majority of referrals for pre-screening and randomization.
CONCLUSIONS AND SCIENTIFIC SIGNIFICANCE
These results support the feasibility of recruiting dually-diagnosed adolescents utilizing a multifaceted approach involving the entire study team.
摘要
背景
本文报告了一项为期 16 周的多地点试验中的招募策略，该试验将渗透压释放型哌甲酯与认知行为疗法联合用于同时患有注意缺陷多动障碍和物质使用障碍的青少年。
方法
采用了多方面的招募策略，针对多个转介来源，使用了激励措施，涉及了众多工作人员，强调了在预筛选期间的治疗联盟，并利用数据根据结果修改策略。总共从 11 个参与地点的 1333 个总转介中随机选择了 303 名青少年。
结果
总体而言，现有的治疗项目来源，包括治疗项目工作人员、社会服务、少年司法系统和心理健康诊所，为预筛选和随机分配提供了大多数转介。
结论和科学意义
这些结果支持了使用多方面的方法招募双重诊断青少年的可行性，该方法涉及整个研究团队。
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