International Lyme and Associated Diseases Society, Bethesda, MD, USA;
Clin Cosmet Investig Dermatol. 2013;6:1-21. doi: 10.2147/CCID.S39017. Epub 2013 Jan 8.
Morgellons disease is an emerging skin disease characterized by formation of dermal filaments associated with multisystemic symptoms and tick-borne illness. Some clinicians hypothesize that these often colorful dermal filaments are textile fibers, either self-implanted by patients or accidentally adhering to lesions, and conclude that patients with this disease have delusions of infestation. We present histological observations and electron microscopic imaging from representative Morgellons disease samples revealing that dermal filaments in these cases are keratin and collagen in composition and result from proliferation and activation of keratinocytes and fibroblasts in the epidermis. Spirochetes were detected in the dermatological specimens from our study patients, providing evidence that Morgellons disease is associated with an infectious process.
莫吉隆斯症是一种新兴的皮肤疾病，其特征是形成与多系统症状和蜱传疾病相关的皮肤丝状物。一些临床医生假设这些通常五颜六色的皮肤丝状物是纺织纤维，要么是患者自行植入的，要么是偶然粘在病变上的，并得出结论认为患有这种疾病的患者有被感染的错觉。我们展示了来自代表性莫吉隆斯症样本的组织学观察和电子显微镜成像，这些发现揭示了这些病例中的皮肤丝状物是角蛋白和胶原蛋白的组成，是由于表皮中的角朊细胞和成纤维细胞的增殖和激活所致。我们的研究患者的皮肤标本中检测到螺旋体，这提供了莫吉隆斯症与感染过程相关的证据。
