The Prince Charles Hospital Adult Cystic Fibrosis Centre, Rode Rd, Chermside, Queensland 4032, Australia.
BMC Pulm Med. 2010 Feb 25;10:8. doi: 10.1186/1471-2466-10-8.
Pandemic Influenza A (H1N1) 2009 is a novel viral infection that emerged in March 2009. This is the first report addressing the clinical course of patients with cystic fibrosis (CF) and H1N1 infection.
All patients with an influenza-like illness (ILI) attending our adult centre during July 2009 were identified. Baseline respiratory function, nutritional status, approach to management and short-term clinical course were recorded.
Most patients experienced a mild course and were able to be managed with antiviral agents as an outpatient. Robust infection control policies were implemented to limit transmission of H1N1 infection within our CF centre. Patients with severe lung disease, poor baseline nutritional reserve and presenting with more than 48 hours of ILI experienced a more severe course. Prompt antiviral therapy within the first 48 hours of illness may have been important in improving outcomes.
This observational study demonstrates that most adults with CF with H1N1 infection had mild clinical courses and recovered rapidly.
甲型 H1N1 流感是一种新型病毒感染，于 2009 年 3 月出现。这是第一份报告，介绍了囊性纤维化 (CF) 患者与 H1N1 感染的临床过程。
在 2009 年 7 月期间，我们鉴定了所有患有流感样疾病 (ILI) 的成年患者。记录了基线呼吸功能、营养状况、管理方法和短期临床过程。
大多数患者经历了轻度病程，并且能够作为门诊患者接受抗病毒药物治疗。实施了严格的感染控制政策，以限制我们 CF 中心内 H1N1 感染的传播。患有严重肺部疾病、基础营养储备不良和 ILI 症状持续超过 48 小时的患者，经历了更严重的病程。在疾病的前 48 小时内及时使用抗病毒治疗可能对改善预后很重要。
这项观察性研究表明，大多数患有 H1N1 感染的成年 CF 患者的临床病程较轻，且迅速恢复。
