四年内障性混浊的发生率和进展：洛杉矶拉丁裔眼病研究。
Four-year incidence and progression of lens opacities: the Los Angeles Latino Eye Study.
机构信息
Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
出版信息
Am J Ophthalmol. 2010 May;149(5):728-34.e1-2. doi: 10.1016/j.ajo.2009.11.012. Epub 2010 Feb 24.
PURPOSE
To estimate the 4-year incidence and progression of lens opacities.
DESIGN
Population-based longitudinal study.
METHODS
A total of 4658 adult Latinos from Los Angeles County were examined at baseline and 4-year follow-up. Examination included assessment of lens opacities using the Lens Opacities Classification System II (LOCS II). Incidences of cortical, nuclear, and posterior subcapsular opacities (with LOCS II scores >or=2) were defined as opacity development in persons without that opacity at baseline. Single and mixed opacities were defined in persons without any opacity at baseline. Incidence of all lens changes included development of at least 1 opacity or cataract surgery among those without any opacity at baseline. Four-year progressions were defined as increase of >or=2 in LOCS II score.
RESULTS
The 4-year incidence of all lens opacities was 14.2%. Four-year incidence of cataract surgery was 1.48%. The incidences were 4.1% for cortical-only, 5.8% for nuclear-only, 0.5% for PSC-only, and 2.5% for mixed. The incidences for any opacities were 7.5% for cortical, 10.2% for nuclear, and 2.5% for PSC. Incidence increased with age (P < .0001 for all). The progressions were 8.5% for cortical, 3.7% for nuclear, and 2.9% for PSC opacities.
CONCLUSIONS
Our Latino population had a higher incidence of nuclear than cortical opacities, but a greater progression of cortical than nuclear opacities. Incidence and progression of PSC was low. Additional understanding of the natural history and progression of various lens opacities will give us a better understanding of the pathogenesis and management of lens opacities.
目的
评估晶状体混浊的 4 年发生率和进展情况。
设计
基于人群的纵向研究。
方法
共对来自洛杉矶县的 4658 名成年拉丁裔人进行了基线和 4 年随访检查。检查包括使用晶状体混浊分类系统 II（LOCS II）评估晶状体混浊。皮质、核和后囊下混浊（LOCS II 评分≥2）的发生率定义为基线时无该混浊的人群中出现混浊的情况。单发性和混合性混浊则定义为基线时无任何混浊的人群。所有晶状体变化的发生率包括在基线时无任何混浊的人群中至少出现 1 种混浊或白内障手术。4 年进展定义为 LOCS II 评分增加≥2。
结果
所有晶状体混浊的 4 年发生率为 14.2%。4 年白内障手术发生率为 1.48%。皮质混浊的发生率为 4.1%，核性混浊为 5.8%，后囊下混浊为 0.5%，混合性混浊为 2.5%。任何混浊的发生率为皮质混浊 7.5%，核性混浊 10.2%，后囊下混浊 2.5%。发生率随年龄增加而增加（所有均 P<.0001）。皮质混浊的进展率为 8.5%，核性混浊为 3.7%，后囊下混浊为 2.9%。
结论
我们的拉丁裔人群中核性混浊的发生率高于皮质性混浊，但皮质性混浊的进展速度快于核性混浊。后囊下混浊的发生率较低。进一步了解各种晶状体混浊的自然史和进展情况，将有助于我们更好地了解晶状体混浊的发病机制和治疗方法。
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