通过多价相互作用实现泛素的多重任务处理。
Multitasking with ubiquitin through multivalent interactions.
机构信息
Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA.
出版信息
Trends Biochem Sci. 2010 Jun;35(6):352-60. doi: 10.1016/j.tibs.2010.01.002. Epub 2010 Feb 22.
Abstract
Ubiquitylation - the post-translational modification of proteins with ubiquitin - serves powerful regulatory roles in eukaryotes. It can label proteins for destruction or activate gene transcription. Despite its versatility, ubiquitin is used to signal for cellular events with exquisite specificity. To achieve both versatility and specificity, ubiquitin signaling pathways use multivalency, namely the coordinated use of multiple interaction surfaces. Multivalent interactions regulate each stage of ubiquitin signaling pathways, and appear within the ubiquitin signal, the ubiquitylated substrate, ubiquitin processing enzymes and ubiquitin recognition proteins.
摘要
泛素化 - 蛋白质与泛素的翻译后修饰 - 在真核生物中发挥着强大的调节作用。它可以标记蛋白质进行破坏或激活基因转录。尽管具有多功能性，但泛素用于信号传导的细胞事件具有极高的特异性。为了实现多功能性和特异性，泛素信号通路使用多价性，即多个相互作用表面的协调使用。多价相互作用调节泛素信号通路的每个阶段，并存在于泛素信号、泛素化底物、泛素处理酶和泛素识别蛋白中。
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