From the Institute of Biochemistry II, Goethe University Frankfurt-Medical Faculty, University Hospital, 60590 Frankfurt am Main and.
From the Institute of Biochemistry II, Goethe University Frankfurt-Medical Faculty, University Hospital, 60590 Frankfurt am Main and
J Biol Chem. 2018 Apr 13;293(15):5404-5413. doi: 10.1074/jbc.TM117.000117. Epub 2017 Nov 29.
Ubiquitination is a widespread post-translational modification that controls multiple steps in autophagy, a major lysosome-mediated intracellular degradation pathway. A variety of ubiquitin chains are attached as selective labels on protein aggregates and dysfunctional organelles, thus promoting their autophagy-dependent degradation. Moreover, ubiquitin modification of autophagy regulatory components is essential to positively or negatively regulate autophagy flux in both non-selective and selective pathways. We review the current findings that elucidate the components, timing, and kinetics of the multivalent role of ubiquitin signals in control of amplitude and selectivity of autophagy pathways as well as their impact on the development of human diseases.
泛素化是一种广泛存在的翻译后修饰，可控制自噬这一主要溶酶体介导的细胞内降解途径中的多个步骤。各种泛素链作为选择性标签附着在蛋白聚集体和功能失调的细胞器上，从而促进它们的自噬依赖性降解。此外，自噬调节成分的泛素修饰对于正向或负向调节非选择性和选择性途径中的自噬流是必不可少的。我们综述了目前的研究结果，这些结果阐明了泛素信号在控制自噬途径的幅度和选择性方面的多价作用的组成、时间和动力学，以及它们对人类疾病发展的影响。
