Lam W L, Rawlins J M, Karoo R O S, Naylor I, Sharpe D T
Department of Plastic Surgery and Burns Research Unit, School of Biomedical Sciences, University of Bradford, Bradford, United Kingdom.
J Hand Surg Eur Vol. 2010 May;35(4):312-7. doi: 10.1177/1753193410362848. Epub 2010 Feb 24.
Luck (1959) described a histological staging system for Dupuytren's disease, classifying the disease into three stages. Previous biochemical and immunochemical studies have detailed the decrease in type III/I collagen ratio with disease progression. Herovici (1963) described a histological stain that produced a differential red/purple and blue colour for type I and III collagen respectively. We stained 15 specimens of Dupuytren's disease and quantified the different collagen types in each using computer analysis. We found a corresponding decrease in the amount of type III collagen as a percentage of the total collagen with disease progression: stage I range 35-49% (mean 38%); stage 2 range 21-33% (mean 27%) and stage 3 range 11-19% (mean 14%). We propose a new staging system based on the relative amount of type III collagen, where stage 1: >35%, stage 2: >20% and <35%, and stage 3: <20%.
勒克（1959年）描述了一种用于掌腱膜挛缩症的组织学分期系统，将该疾病分为三个阶段。先前的生化和免疫化学研究详细阐述了随着疾病进展，III型/I型胶原蛋白比例的降低。赫罗维奇（1963年）描述了一种组织学染色方法，该方法分别对I型和III型胶原蛋白产生不同的红/紫色和蓝色。我们对15个掌腱膜挛缩症标本进行染色，并使用计算机分析对每个标本中的不同胶原蛋白类型进行定量。我们发现随着疾病进展，III型胶原蛋白占总胶原蛋白的百分比相应降低：I期范围为35 - 49%（平均38%）；II期范围为21 - 33%（平均27%），III期范围为11 - 19%（平均14%）。我们基于III型胶原蛋白的相对含量提出了一种新的分期系统，其中I期：>35%，II期：>20%且<35%，III期：<20%。
