Fulda Simone
Ulm University, Children's Hospital, Eythstrasse 24, 89075 Ulm, Germany.
Int J Cell Biol. 2010;2010:370835. doi: 10.1155/2010/370835. Epub 2010 Feb 18.
One of the hallmarks of human cancers is the intrinsic or acquired resistance to apoptosis. Evasion of apoptosis can be part of a cellular stress response to ensure the cell's survival upon exposure to stressful stimuli. Apoptosis resistance may contribute to carcinogenesis, tumor progression, and also treatment resistance, since most current anticancer therapies including chemotherapy as well as radio- and immunotherapies primarily act by activating cell death pathways including apoptosis in cancer cells. Hence, a better understanding of the molecular mechanisms regarding how cellular stress stimuli trigger antiapoptotic mechanisms and how this contributes to tumor resistance to apoptotic cell death is expected to provide the basis for a rational approach to overcome apoptosis resistance mechanisms in cancers.
人类癌症的一个标志是对细胞凋亡具有内在或获得性抗性。逃避细胞凋亡可能是细胞应激反应的一部分，以确保细胞在暴露于应激刺激时存活。抗凋亡可能有助于致癌、肿瘤进展以及治疗抗性，因为目前大多数抗癌疗法，包括化疗以及放疗和免疫疗法，主要通过激活癌细胞中的细胞死亡途径（包括凋亡）来发挥作用。因此，更好地理解细胞应激刺激如何触发抗凋亡机制以及这如何导致肿瘤对凋亡性细胞死亡产生抗性的分子机制，有望为克服癌症中抗凋亡机制的合理方法提供基础。
