干细胞分裂的极性：组织稳态中的不对称干细胞分裂。
Polarity in stem cell division: asymmetric stem cell division in tissue homeostasis.
机构信息
Life Sciences Institute, Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109, USA.
出版信息
Cold Spring Harb Perspect Biol. 2010 Jan;2(1):a001313. doi: 10.1101/cshperspect.a001313.
Abstract
Many adult stem cells divide asymmetrically to balance self-renewal and differentiation, thereby maintaining tissue homeostasis. Asymmetric stem cell divisions depend on asymmetric cell architecture (i.e., cell polarity) within the cell and/or the cellular environment. In particular, as residents of the tissues they sustain, stem cells are inevitably placed in the context of the tissue architecture. Indeed, many stem cells are polarized within their microenvironment, or the stem cell niche, and their asymmetric division relies on their relationship with the microenvironment. Here, we review asymmetric stem cell divisions in the context of the stem cell niche with a focus on Drosophila germ line stem cells, where the nature of niche-dependent asymmetric stem cell division is well characterized.
摘要
许多成人干细胞通过不对称分裂来平衡自我更新和分化，从而维持组织内稳态。不对称的干细胞分裂取决于细胞内和/或细胞环境中的不对称细胞结构（即细胞极性）。特别是，作为它们所维持的组织的居民，干细胞不可避免地处于组织架构的背景下。事实上，许多干细胞在其微环境或干细胞龛中具有极化性，它们的不对称分裂依赖于它们与微环境的关系。在这里，我们以果蝇生殖干细胞为重点，在干细胞龛的背景下综述不对称干细胞分裂，其中依赖于龛的不对称干细胞分裂的性质得到了很好的描述。
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