雌激素与自身免疫性疾病。
Estrogen and autoimmune disease.
机构信息
Department of Internal Medicine, The University of Missouri, 2120 Southern Star Loop, Las Cruces, NM 88011, USA.
出版信息
Clin Rev Allergy Immunol. 2011 Feb;40(1):60-5. doi: 10.1007/s12016-010-8199-x.
Estrogenic hormones possess both immunostimulating and immunosuppressive properties. In systemic lupus erythematosus (SLE), pregnancy is associated with disease flares. In some situations, exogenous estrogen predisposes to development of new SLE, flares of preexisting SLE, and thromboses in susceptible individuals. In contrast, treatment with exogenous estrogen protects postmenopausal rheumatoid arthritis (RA) patients from active RA and osteoporosis. The search for estrogen-like compounds with anti-inflammatory properties may expand treatment options in RA.
雌激素具有免疫刺激和免疫抑制特性。在系统性红斑狼疮（SLE）中，妊娠与疾病加重有关。在某些情况下，外源性雌激素易导致新的 SLE、已有的 SLE 发作和易感个体的血栓形成。相比之下，外源性雌激素治疗可使绝经后类风湿关节炎（RA）患者免受活动性 RA 和骨质疏松症的影响。寻找具有抗炎特性的类雌激素化合物可能会扩大 RA 的治疗选择。
Zotero 插件