National Institute of Biological Sciences, No. 7 Science Park Road, Zhongguancun Life Science Park, Beijing, 102206, China.
Stem Cell Rev Rep. 2010 Sep;6(3):345-50. doi: 10.1007/s12015-010-9128-3.
Tissue-specific adult stem cells are responsible for generating a range of various differentiated cells during their life time; these cells are intimately associated with niche for maintenance and function. Recent studies of germline stem cell niches in Drosophila gonad suggest that stem cells within a niche constantly compete with each other for niche occupancy. Competition within a niche occurs between same type of stem cells as well as different types. In both cases, cell adhesion molecules are critical in mediating the competition.
组织特异性成体干细胞在其一生中负责产生一系列不同的分化细胞；这些细胞与维持和功能的小生境密切相关。最近对果蝇生殖干细胞小生境的研究表明，小生境内的干细胞之间为了小生境的占有而不断相互竞争。小生境内的竞争发生在同种类型的干细胞以及不同类型的干细胞之间。在这两种情况下，细胞黏附分子在介导竞争中都起着关键作用。
