Department of Neurological Sciences, University of Bologna, via U. Foscolo 7, 40123, Bologna, Italy.
Neurol Sci. 2010 Jun;31(3):327-36. doi: 10.1007/s10072-010-0224-6. Epub 2010 Feb 25.
The objective is to evaluate the prognosis of subjective cognitive complaints (SCC) patients during 4-year follow-up. A prospective study on 92 SCC patients investigating their cognitive, affective and behavioural aspects. SCC patients were classified as having no objective cognitive impairment (NOCI), mild cognitive impairment (MCI), or subtypes of MCI.
43 patients were found to have NOCI and 49 MCI. During the follow-up, 45.5% of NOCI patients remained unchanged, 13.9% were diagnosed as MCI and only one progressed to dementia. Of the MCI patients, 32.3% remained stable, 18.4% became demented and 4% reverted to NOCI. Visual attention, behavioural memory, long-term verbal memory, apathy and caregiver distress, provided independent predictors of progression to dementia.
在 4 年随访期间评估主观认知主诉 (SCC) 患者的预后。对 92 例 SCC 患者进行前瞻性研究，调查其认知、情感和行为方面。将 SCC 患者分为无客观认知障碍 (NOCI)、轻度认知障碍 (MCI)或 MCI 亚型。
发现 43 例患者无客观认知障碍，49 例 MCI。在随访期间，45.5%的 NOCI 患者保持不变，13.9%被诊断为 MCI，只有 1 例进展为痴呆。MCI 患者中，32.3%保持稳定，18.4%发展为痴呆，4%恢复为 NOCI。视觉注意力、行为记忆、长期言语记忆、淡漠和照顾者痛苦为进展为痴呆的独立预测因素。
