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嗅觉识别作为认知障碍的生物标志物:来自健康衰老、主观认知衰退和轻度认知障碍的见解

Olfactory Identification as a Biomarker for Cognitive Impairment: Insights from Healthy Aging, Subjective Cognitive Decline, and Mild Cognitive Impairment.

作者信息

Bouhaben Jaime, Delgado-Lima Alice Helena, Delgado-Losada María Luisa

机构信息

Experimental Psychology, Cognitive Processes and Speech Therapy Department, Faculty of Psychology, Complutense University of Madrid, 28223 Pozuelo de Alarcón, Spain.

出版信息

Eur J Investig Health Psychol Educ. 2024 Nov 29;14(12):2978-3000. doi: 10.3390/ejihpe14120196.

DOI:10.3390/ejihpe14120196
PMID:39727504
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11675861/
Abstract

: This study aims to investigate the relationship between olfactory identification (OI) and cognitive impairment by examining OI abilities across various stages of cognitive deterioration. : A total of 264 participants were divided into three groups based on cognitive status: cognitively healthy, subjective cognitive, and mild cognitive impairment. All participants were assessed using the Sniffin' Sticks Olfactory Identification test and a comprehensive neuropsychological test battery. : Our results highlight the main effects of age and cognitive status on OI scores. Regarding cognitive abilities, OI is associated with measures of short-term memory, long-term, working memory, and selective attention. Finally, logistic regression models showed that OI is a significant predictor for discriminating SCD from CH, MCI from CH, and MCI from SCD. : These findings suggest the addition of olfactory identification measures in neuropsychological assessments could improve the early detection of individuals at risk for cognitive impairment.

摘要

本研究旨在通过检查认知衰退各阶段的嗅觉识别(OI)能力,探讨嗅觉识别与认知障碍之间的关系。共有264名参与者根据认知状态分为三组:认知健康组、主观认知组和轻度认知障碍组。所有参与者均使用嗅觉棒嗅觉识别测试和一套全面的神经心理测试进行评估。我们的结果突出了年龄和认知状态对OI分数的主要影响。关于认知能力,OI与短期记忆、长期记忆、工作记忆和选择性注意的测量指标相关。最后,逻辑回归模型表明,OI是区分主观认知衰退与认知健康、轻度认知障碍与认知健康以及轻度认知障碍与主观认知衰退的重要预测指标。这些发现表明,在神经心理评估中增加嗅觉识别测量指标可以改善对认知障碍风险个体的早期检测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ab0/11675861/3d55f06cb1fa/ejihpe-14-00196-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ab0/11675861/9416f1cc34de/ejihpe-14-00196-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ab0/11675861/0f7970c86056/ejihpe-14-00196-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ab0/11675861/3d55f06cb1fa/ejihpe-14-00196-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ab0/11675861/9416f1cc34de/ejihpe-14-00196-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ab0/11675861/0f7970c86056/ejihpe-14-00196-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ab0/11675861/3d55f06cb1fa/ejihpe-14-00196-g003.jpg

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Brain Behav. 2024 May;14(5):e3524. doi: 10.1002/brb3.3524.
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The role of olfactory dysfunction in mild cognitive impairment and Alzheimer's disease: A meta-analysis.嗅觉功能障碍在轻度认知障碍和阿尔茨海默病中的作用:一项荟萃分析。
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An examination of semantic performance in mild cognitive impairment progressors and nonprogressors.
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Olfaction and declarative memory in aging: a meta-analysis.嗅觉与衰老中的陈述性记忆:一项荟萃分析。
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