Tian Xiang-Rong, Tang Hai-Feng, Li Yu-Shan, Lin Hou-Wen, Ma Ning, Zhang Wei, Yao Min-Na
Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
J Asian Nat Prod Res. 2009 Dec;11(12):1005-12. doi: 10.1080/10286020903207050.
From the marine bryozoan Bugula neritina inhabiting South China Sea, a new ceramide named (2S,3R,4E)-2-(14'-methyl-pentadecanoylamino)-4-octadecene-l,3-diol (1) and a new cerebroside named 1-O-(beta-D-glucopyranosyl)-(2S,3R,4E)-2-(heptadecanoylamino)-4-octadecene-l,3-diol (6), together with one known ceramide (2) and three known cerebrosides (3, 4, and 5), were isolated. Their structures were deduced by extensive spectral analysis and chemical evidences. Compound 1 is branched with a methyl [-CH(CH(3))(2)] in the fatty acid moiety, which is a rare structural feature among ceramides. Compound 6 is a new cerebroside with 17 carbons in the fatty acid moiety, while 5 is a new natural product which was isolated from a natural origin for the first time.
从栖息于中国南海的海洋苔藓虫类多室草苔虫（Bugula neritina）中，分离得到一种名为(2S,3R,4E)-2-(14'-甲基-十五烷酰氨基)-4-十八碳烯-1,3-二醇（1）的新神经酰胺和一种名为1-O-(β-D-吡喃葡萄糖基)-(2S,3R,4E)-2-(十七烷酰氨基)-4-十八碳烯-1,3-二醇（6）的新脑苷脂，以及一种已知神经酰胺（2）和三种已知脑苷脂（3、4和5）。通过广泛的光谱分析和化学证据推导了它们的结构。化合物1在脂肪酸部分带有一个甲基[-CH(CH(3))(2)]支链，这在神经酰胺中是一种罕见的结构特征。化合物6是脂肪酸部分含有17个碳的新脑苷脂，而化合物5是首次从天然来源分离得到的新天然产物。
